Monitoring estrogenic effects: a genomics approach. Environmental Health Perspectives,
Mechanical improvements in high-throughput applications continue to increase the utility of the microarray approach for investigating toxic effects on genes. But improvements in the content of arrays may be the key to maximizing the value of these technologies, according to a paper in this month’s issue [EHP 111:863–870]. In the report, researchers at Abbott Laboratories and Rosetta Inpharmatics, led by senior research scientist Jeffrey Waring, lay out the development of a microarray specifically constructed for studying the effects of hepatotoxicants. Work in toxicogenomics has so far focused primarily on hepatotoxicity because of the importance of the liver as a site of toxic response. Whereas earlier toxicology-focused arrays were put together using DNA libraries from normal or diseased tissues, building a library from toxicant-challenged animals is a new approach.