Keywords: single-walled carbon nanotubes, SWNTs, antisense oligodeoxynucleotides, ASODNs, gold nanoparticles, GNPs, transfection vector, multifunctional vectors, cancer therapy, nanotechnology, transfection vectors, cancer cells, induced apoptosis, cancer treatment
Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials
Introduction. A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods. Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results. The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions. This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.