Keywords: polymorphic cellulose modifications, Kollicoat SR 30 D, STAVEX, soft compaction, Presster compaction simulator, multiple unit pellet systems, MUPS, drug release, drug delivery, coated pellets, polymorphic modification, controlled release pellets
Multiple unit pellet systems (MUPS) obtained by soft compaction of two polymorphic cellulose modifications as coated pellets: influence of the polymorphic modification in MUPS on disintegration time and drug release
The compaction of UICEL-A/102 and MCC 102 coated pellets into multiple unit pellet systems (MUPS) is presented in this work. MCC 102 and UICEL-A/102 were separately mixed with sodium diclofenac, pelletised and afterwards coated with a water suspension of Kollicoat® SR 30 D. 30%-50% of the so produced coated pellets were embedded in 40%-60% of MCC 102 powder (cushioning) and 10% of either STA-RX® 1500 or UICEL-A/102 (disintegrant). Finally, the tabletting mixtures were compacted into MUPS using a PressterTM Compaction Simulator. Both UICEL-A/102 and MCC 102 MUPS resulted to be mechanically robust (crushing strength of 70-100 N), fast disintegrating in water and maintained the same release profile and similar superficial and inner morphology compared to the uncompressed subunits. UICEL-A/102 proved to be more appropriate as filler for immediate release pellets and MUPS, whereas MCC 102 confirmed to be advantageous filler for controlled release pellets in MUPS.