Non-woven electrostatic media for chromatographic separation of biological particles

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Courtesy of Argonide Corporation

The filtration and separation of biological particles has been estimated as 40% of the cost in the manufacture of pharmaceuticals. Liquid chromatography that is the principal method for separating biological particles uses a permanent phase of ultrafine adsorbent particles such as porous silica or resin spheres with particle sizes down to about 1 micron. Speed and resolution are two competing performance factors in conventional chromatography using porous media. One feature is often achieved by sacrificing the other. Conventional wisdom focuses on surface area as the defining element for “dynamic capacity” when determining product throughput employing conventional chromatographic media.

Nano alumina media – An electropositive fibrous media has been developed for water filtration that is capable of retaining sub-micron particles at high flow rates. The active component in the filter media is a nano alumina fiber, only 2 nm in diameter and about 250-300 nm long that are attached to a microglass fiber. Figure 1 shows the nanofibers that appear as fuzz on the microglass. The nanoalumina is aluminum oxide monohydrate (AlOOH), also known as the pseudoboehmite.

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