Inderscience Publishers

Part 2: Effectiveness of a novel gentamicinpalmitate coating on biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis

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Courtesy of Inderscience Publishers

Commercially available Tilastan® layers of uncemented implants were coated with gentamicinpalmitate; no biofilm formation occurred with the novel coating. Gentamicinpalmitate is anti-infective and successfully inhibits biofilm formation of Staphylococcus aureus and/or Staphylococcus epidermidis. The gentamicin (as sulphate) of well known antibiotic impregnated bone cements and the gentamicin of the novel coating (as palmitate) that is described show comparable anti-infective behaviour within the proliferation assay according to ISO DIN EN 17025. Furthermore, the gentamicinpalmitate coating is biocompatible according to ISO DIN EN 10993.

Keywords: gentamicinpalmitate coating, gentamicin base, microporous surfaces, gentamicinsulphate, gentamicin release, uncemented titanium implants, PMMA bone cement, Tilastan, anti-infective coating, health economics, hip stems, knees, biomaterials, polymethyl methacrylate, infection risk, Staphylococcus aureus, Staphylococcus epidermidis, proliferation test

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