Nickel and antimony doped tin dioxide is a novel anodic material for its good performance of electrochemical ozone generation and direct electro-catalytic oxidation. Electro-catalytic oxidation of phenol on this novel nickel-antimony doped tin dioxide electrode is presented here. The morphology and composition of the electrode are characterized. The effects of applied current densities on phenol degradation rate, energy consumption and coulomb efficiency are discussed. In 0.1 M sulfuric acid, after 4 h electrolysis with current density of 25 mA cm-1, 90% phenol is removed. And with current density of 20 mA cm-1, the highest energy efficiency of 6.85 g kWh-1 and the highest coulomb efficiency of 6.87 mg C-1 are obtained. The effect of current densities on TOC removal is also discussed.