Constant exposure to air contaminants may cause of respiratory illnesses and trigger cardiovascular problems. In the last years, norms have been proposed to reducing air pollution, nevertheless, diseases and death cases are still occurring. It seems that there is a relation between excessive levels of PM10 and the increment of acute respiratory infections (ARI). Mexican and American Health agencies are working together on the public health project Frontera XXI (Frontier XXI). The project has the purpose of monitoring the main polluting agents behavior (03, CO, SO2, NOx, PM10 and PST). Total suspended particles (TSP) such as PM10 and lead. It will be possible to know what effects these pollutants have on Mexicali and Calexico residents’ health. According to studies previously done by SEMARNAP (Mexico) and EPA (USA) in the last decade, it was discovered that levels of PM10 have exceeded the normal standards, however, it was not demonstrated that there is a relation of the air pollutants with people’s health. This particular situation made the UABC- Engineering Institute and ISESALUD-chapter Mexicali to launch a joint research whose objective is to detect how, and to what extent, PM10 affects human air passages. This project is rather an evaluation based on a modeling pattern that can show correlation of PM10 and ARI cases. For this reason, the principal meteorological variables were involved as they are important factors that contribute to air pollution. Some studies have proved that temperature is the key meteorological variable that greatly influences relative humidity during the process of dispersion of PM10 the occurrence of ARI.