John Wiley & Sons, Ltd.

Prediction of the bioconcentration factor in common carp (Cyprinus carpio L.) using data from the dietary exposure bioaccumulation fish test

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An approach to predicting the bioconcentration factor (BCFPRE) from the predicted uptake rate constant (k1Pre) and the depuration rate constant measured in the dietary exposure bioaccumulation fish test (k2Dietary) [BCFPRE = k1Pre/k2Dietary] is proposed in the test guideline 305 of the Organisation for Economic Co‐operation and Development Guidelines for Testing of Chemicals. In the present study, we collected BCF data of 197 test chemicals from Japan's Chemical Substances Control Law database, and to demonstrate how the BCFPRE compares to experimentally derived BCF under optimum conditions, 48 of 197 test chemicals including a many of studies that could be considered as problematic, were excluded from the analysis. We calculated k1Pre by 22 published prediction methods and shows that the correlation between experimental uptake rate constants (k1Aqueous) and k1Pre for all prediction methods were very low and were statistically non‐significant (p > 0.05). We also selected three prediction methods which gave relatively good values for the geometric mean of k1Pre/k1Aqueous and calculated values of BCFPRE for 12 test chemicals. Linear relationships (p < 0.05) were presented between logarithm of experimental and predicted BCF. The correlation coefficients of growth‐corrected experimental and predicted BCF were tending to be higher than those of not growth corrected values. For some test chemicals, use of predicted BCF led to a bioaccumulation classification different from that according to existing regulatory criteria. Environ Toxicol Chem © 2014 SETAC

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