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Preparation of human serum albumin nanospheres labelled with 188Re

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The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter 188Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, after 45 min. at 75°C, the labelling yields were more than 95%; also, 97% of the 188Re is bound to the albumin nanospheres at 20 h after labelling.

Keywords: albumin nanospheres, labelling methods, 188Re, radiotherapy, endoradiotherapy, tumours, radiolabelling, beta emitters, drug delivery, nanoparticles

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