John Wiley & Sons, Ltd.

Relative sensitivities among avian species to individual and mixtures of AhR‐active compounds

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Dioxins and dioxin‐like compounds (DLCs) are potent toxicants to most vertebrates. Sensitivities to DLCs vary among species. Here sensitivities of avian species (chicken [Gallus gallus], ring‐necked pheasant [Phasianus colchicus], Japanese quail [Coturnix japonica]) to some polychlorinated dibenzo‐p‐dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were determined by use of species‐specific, in vitro, transactivation assays based on a luciferase reporter gene (LRG) under control of species‐specific aryl hydrocarbon receptors (AhRs). 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) was not the most potent inducer of toxic effects in ring‐necked pheasant or Japanese quail. Especially for Japanese quail, the relative potency (ReP) values of most of 9 PCDD/Fs tested were greater than TCDD. The rank order of avian species sensitivities to DLCs was chicken > ring‐necked pheasant > Japanese quail. Effects of binary mixtures of TCDD, 2,3,7,8‐tetrachlorodibenzofuran (2,3,7,8‐TCDF) and 2,3,4,7,8‐pentachlorodibenzofuran (2,3,4,7,8‐PeCDF) were strictly additive. Moreover, we also found that the primary DLCs that were responsible for most of the potency of DLCs mixtures can be deduced by use of ordination in a multi‐dimensional space defined by the avian species sensitivities. Overall, the ReP and the species sensitivities of these chemicals could guide risk assessments to wild species when exposure to mixtures of DLCs in the environment. This article is protected by copyright. All rights reserved

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