John Wiley & Sons, Ltd.

Saving two birds with one stone — using active substance avian acute toxicity data to predict formulated plant protection product toxicity

0
Environmental safety assessments for exposure of birds require the provision of acute avian toxicity data on both the pesticidal active substance and formulated products. As an example, in Europe testing on the formulated product is waived using an assessment of data for the constituent active substance(s). Globally this is often not the case as some countries require acute toxicity tests with every formulated product, thereby triggering animal welfare concerns from unnecessary testing. A database of 383 formulated products were compiled from acute toxicity studies conducted with northern bobwhite (Colinus virginianus) or Japanese quail (Coturnix japonica) (unpublished regulatory literature). Of the 383 formulated products studied 159 contained only active substances considered as “functionally non‐toxic” (LD50 > highest dose tested). Of these, 97% had formulated product LD50 values of >2000 mg formulated product/kg (limit dose), indicating no new information was obtained in the formulated product study. Further, defined (point estimated) LD50 values for formulated products were compared to LD50 values predicted from toxicity of the active substance(s). This demonstrated that predicted LD50 values were within 2‐ and 5‐fold of the measured formulated product LD50 values in 90 and 98% of cases respectively. This analysis demonstrates that avian acute toxicity testing of formulated products is largely unnecessary and should not be routinely required to assess avian acute toxicity. In particular; where active substances are known to be ‘functionally non‐toxic’ further formulated product testing adds no further information and unnecessarily increases bird usage in testing. A further analysis highlights that significant reductions (61% in this dataset) could be achieved by using a sequential testing design (OECD TG223), as opposed to established single stage designs. Environ Toxicol Chem © 2014 SETAC

Customer comments

No comments were found for Saving two birds with one stone — using active substance avian acute toxicity data to predict formulated plant protection product toxicity. Be the first to comment!