John Wiley & Sons, Ltd.

Short term fish reproduction assays with methyl tertiary butyl ether (MTBE) with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity

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This paper reports on short‐term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under Good Laboratory Practice and in accordance with OECD and USEPA test guidelines. Results of the first study demonstrated that exposure to a high test concentration (147 mg/L) of MTBE impaired reproductive output of female zebrafish, evident by a reduction in fecundity. However, based on the endpoints evaluated in this study, there was no supporting evidence to indicate that this effect was due to disruption or interaction with the endocrine system. In a second study, fathead minnows exposed to a wider but lower range of test concentrations showed no effects on any reproductive parameter of male or female fish, at the maximum recommended testing concentration of 100 mg/L (62 mg/L measured). The results of these two guideline studies indicate MTBE does not interact with the hypothalamic‐pituitary‐gonadal axis of zebrafish or fathead minnow. This article is protected by copyright. All rights reserved

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