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Study of delayed effects induced by accelerated 12C ions with an energy of 200 MeV/n and X-rays on mice in vivo

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In the present work, we investigated the delayed effects induced by accelerated 12C ions with energy of 200 MeV/n and X-rays on mice. Dose dependence, ability of the adaptive response (AR) induction and genomic instability in F1 generation were studied by the micronucleus test in polychromatic erythrocytes in bone marrow. Irradiation by carbon ions with doses of 0.1, 0.2, 0.5, 1 and 1.5 Gy was induced by the accelerator 'Nuclotron' and irradiation by X-rays with the same doses – on the RUM device. The experiments demonstrated that (a) at low doses (0–0.5 Gy), both dose dependences of cytogenetic damage induction can be fitted by a linear regression and almost coincide, (b) both these types of radiation induce AR and (c) they lead to an increase in sensitivity to additional irradiation with a dose of 1.5 Gy of X-radiation and the absence of AR in the F1 generation.

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