Surface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, aluminum, and concrete surfaces contaminated with alkaloids (nicotine) was performed using LC/MS (Liquid Chromatography/Mass Spectrometry) according to Environmental Protection Agency (EPA) SW-846 Methods: 3500C (Sampling) and 8321B (Analysis).
Hazardous Materials Relevance
Nicotine is an aromatic (pyridine derivative) alkaloid produced by the nightshade family of plants such as tobacco. Nicotine stimulates production of cytochrome P450 liver enzymes during metabolism and possesses high oral and topical toxicities in comparison to other alkaloids. Nicotine was chosen as a representative alkaloid; DeconGel is expected to have similar efficacy towards the wide range of alkaloids.
- Excellent surface decontamination was achieved by applying DeconGel 1101 onto surfaces contaminated with alkaloids (nicotine) resulting in encapsulation of contaminants by DeconGel’s active components. Decontamination efficacies of DeconGel 1101 were from 99.5% (on concrete) to 99.8% (on aluminum) to 99.8% (on stainless steel) for Nicotine determined by residual swipe analysis.
- Optimized experimental and analytical methods were successfully developed following standardized EPA sampling and analysis methods as guidelines for determination of organic compounds dissolved in a suitable solvent able to completely solvate nicotine as well as DeconGel components. When deemed necessary, experimental methods were customized to afford complete dissolution of organic contaminants. Additionally, analytical methods and associated equipment-LC column, LC gradient program, MS sample ionization parameterswere appropriately developed to ensure accurate decontamination efficacy determination of DeconGel.
Table 1 shows the decontamination efficacies of DeconGel 1101 on stainless steel, aluminum, and concrete surfaces contaminated with alkaloids (nicotine) as determined by residual swipe testing and direct DeconGel analysis.