John Wiley & Sons, Ltd.

The chronic effects of hydroxypropyl‐B‐cyclodextrin on the reproduction of the American flagfish (Jordanella floridae) over one complete life‐cycle

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Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has become very important in the field of aquatic toxicology. Hydroxylpropyl‐β‐cyclodextrin (HPβCD) is an amphiphilic, toroidal shaped molecule with the ability to form non‐covalent inclusion complexes with a variety of guest molecules. HPβCD can reduce volatility as well as improve the aqueous solubility of apolar guest compounds and is an emerging PPCP. As such, HPβCD is the active ingredient in Febreze, Procter & Gamble, and is extensively used as an excipient in the pharmaceutical industry. With the potential for entering the environment through wastewater treatment plant (WWTP) effluent, HPβCD poses an unknown risk to non‐target aquatic biota. A 145‐day chronic full life‐cycle exposure using American flagfish (Jordanella floridae) was completed using flow‐through nominal concentrations of 0 µg/L – control, 5 µg/L, 16 µg/L, 50 µg/L, 160 µg/L, 500 µg/L, and 1600 µg/L of HPβCD maintained via a peristaltic pump. Fecundity, growth, and LSI were all monitored with no significant difference between treatments and controls (P > 0.05). However, a significant increase in the GSI was observed in females exposed to HPβCD (P ≤ 0.05). Reduced offspring growth was observed when exposed in the same manner as the parental generation (P ≤ 0.05). Furthermore, an acute copper toxicity challenge assay was conducted on second generation flagfish larvae and a decrease in copper tolerance was observed in larval progeny from parents exposed to HPβCD. This article is protected by copyright. All rights reserved

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