This paper uncovers the scientific foundation of traditional systems of Indian medicine: Siddha and Ayurveda, from core principles shared in modern control systems engineering. Grand challenges of modern healthcare are motivating a paradigm shift towards systems of systems (SoS) approaches. The recent emergence of modern systems biology and the concomitant growth of evidence-based research in ancient systems of holistic medicine such as Siddha and Ayurveda, practiced in India for over 5,000 years, exemplify this shift. This paper reveals a
, inscribed from principles of control systems engineering, to comprehend the scientific foundations of the ancient
of Siddha and Ayurveda. This discovery provides a much-needed integrative framework, across east and west, ancient and modern, to develop a systems medicine that overcomes the reductionism of modern healthcare.
Keywords: traditional medicine, siddha, ayurveda, complementary and alternative medicine, CAM, systems biology, systems theory, whole cell modelling, Dosha, Prakriti, multi-scale modelling, healthcare system, control systems engineering, systems of systems engineering, SoSE