Keywords: Chernobyl accident, XRCC1, XRCC3, XPD gene polymorphisms, non–cancer diseases, DNA repair genes, nuclear power plants, NPPs, nuclear accidents, nuclear energy, nuclear power, acute radiation syndrome, chronic gastritis, chronic hepatitis, chronic obstructive lung disease, chronic bronchitis, somatic disease, radiation exposure
The significance of DNA repair genes polymorphisms on development of non–cancer pathology in Chornobyl nuclear power plant accident sufferers and convalescents of acute radiation syndrome
The aim of the study was to find an association between XRCC1 (Arg399Gln), XRCC3 (Thr241Met) and XPD (Lys751Gln) gene polymorphisms and non–cancer diseases in 87 sufferers of the Chornobyl nuclear power plant accident using polymerase chain reaction–restriction fragment–length polymorphism analysis. As controls, 109 healthy donors were studied. The distribution of studied polymorphisms was not significantly different in sufferers and controls. Among sufferers, XRCC1 (Gln399Gln) genotype was associated with development of chronic gastritis (p = 0.001) and chronic hepatitis (p = 0.006); XPD (Gln751Gln) genotype had protective effect for development of chronic obstructive lung disease and chronic bronchitis (p = 0.001). No association was found between XRCC3 (Thr241Met) polymorphisms and somatic disease in observed patients. The data obtained showed a possible modifying role of XRCC1 and XPD gene polymorphisms for the development of non–cancer pathology in radiation–exposed persons.