microRNAs (miRNAs) are abundant, 21-nucleotide, noncoding regulatory RNAs. Each miRNA may regulate hundreds of mRNA targets, but the identities of these targets and the processes they regulate are poorly understood. Here we have explored the use of microarray profiling and functional screening to identify targets and biological processes triggered by the transfection of human cells with miRNAs. We demonstrate that a family of miRNAs sharing sequence identity with miRNA-16 (miR-16) negatively regulates cellular growth and cell cycle progression. miR-16-down-regulated transcripts were enriched with genes whose silencing by small interfering RNAs causes an accumulation of cells in G0/G1. Simultaneous silencing of these genes was more effective at blocking cell cycle progression than disruption of the individual genes. Thus, miR-16 coordinately regulates targets that may act in concert to control cell cycle progression.
- American Society for Microbiology
- Transcripts targeted by the microrna-16 family cooperatively ...
Transcripts targeted by the microrna-16 family cooperatively regulate cell cycle progression
Courtesy of American Society for Microbiology
Study: 100% Renewable Electricity System is the Cheapest Option for South America
Transitioning to a fully renewable electricity system is possible for South America by 2030. A study by Lappeenranta University of Technology (LUT) and VTT Technical Research Centre of Finland Ltd. also shows that a 100 percent renewable system (100% RE) is the cheapest electricity production option and can be achieved with very little energy storage. "South America has a unique renewable energy resource base since one of the best wind sites globally is in Patagonia, the best solar energy sites are in the...
When OSHA Visits--Part 2
Continuing Our Guide for New Plant Safety Managers On Monday, we took a closer look at the first few steps of an on-site OSHA visit, including the opening conference and records review. (Refresh your memory on that post here.) As a new plant safety manager, being prepared in a situation like this is key, and we want to make sure you have the tools and information you need. Now let’s take a look at the remaining two portions of the visit—the walk-around inspection and the closing conference. Walk-...
What To Do When OSHA Arrives - Part 1
Continuing Our Guide for New Plant Safety Managers You have been the new plant safety manager for a little over two months. During this timeframe you have had the opportunity to review the limited number of safety procedures left in your office by your predecessor and you are beginning to move forward with your safety responsibilities by following the requirements in the procedures. As part of the Plant Manager’s commitment to safety (our second blog of this series) you have had regularly scheduled...
Power curve measured and verified – Case Study
In 2010 RSE SpA (Energy System Research Inc.) within a Program Agreement with the Italian Ministry of Economic Development started ameasurement campaign on a Libellula wind plantinstalled in Tuscany. The campaign lasted 1 ½ years and during this time RSE measured the turbine’s power curve following the requirements of the relevant IEC Standard (EN 61400-12-1 – EN 61400-2). The results of this study have proven that themeasured power curvecorresponds to the theoretical curve given by Aria. The...
Sweden Proposes Reporting Requirements for Nanomaterials
On December 1, 2015, the Swedish Chemicals Agency (KEMI) announced that it proposed to the government that those who report chemical products to the products register would, in addition to the information that is currently reported, also provide additional information regarding any nanomaterials contained in the product. According to the English summary in KEMI’s report, the proposal covers nanomaterials that have been intentionally added to the product, regardless of concentration. Under the proposal,...