microRNAs (miRNAs) are abundant, 21-nucleotide, noncoding regulatory RNAs. Each miRNA may regulate hundreds of mRNA targets, but the identities of these targets and the processes they regulate are poorly understood. Here we have explored the use of microarray profiling and functional screening to identify targets and biological processes triggered by the transfection of human cells with miRNAs. We demonstrate that a family of miRNAs sharing sequence identity with miRNA-16 (miR-16) negatively regulates cellular growth and cell cycle progression. miR-16-down-regulated transcripts were enriched with genes whose silencing by small interfering RNAs causes an accumulation of cells in G0/G1. Simultaneous silencing of these genes was more effective at blocking cell cycle progression than disruption of the individual genes. Thus, miR-16 coordinately regulates targets that may act in concert to control cell cycle progression.
- American Society for Microbiology
- Transcripts targeted by the microrna-16 family cooperatively ...
Transcripts targeted by the microrna-16 family cooperatively regulate cell cycle progression
Courtesy of American Society for Microbiology
Meyer helps keep the lights on for almost 1 million Americans - Case Study
Iowa’s largest energy company, located in Council Bluffs Iowa, provides service to 746,000 electric customers in a 10,600-square mile area in Iowa, Illinois, South Dakota and Nebraska. When issues arise from downed plants, their customers feel the full extent. It’s critical for this energy company to ensure their daily operations never experience downtime.When the energy company purchased double flapgate valves, they were not expecting an established company to fall short of expectations. Issues...
Mejora Al Sistema de Aireación Elimina Malos Olores en Meixcali, Baja California, Mexico
Resumen: La Comisión Estatal de Servicios Públicos de Mexicali (CESPM) es un Organismo Público Descentralizado del Gobierno del Estado de Baja California. Tiene la función de atender la planeación, construcción, operación y mantenimiento de los sistemas de potabilización de agua, su distribución, captación de agua residual y su tratamiento en el municipio de Mexicali ubicado en Baja California, México. La Planta de Tratamiento de Aguas...
Study: 100% Renewable Electricity System is the Cheapest Option for South America
Transitioning to a fully renewable electricity system is possible for South America by 2030. A study by Lappeenranta University of Technology (LUT) and VTT Technical Research Centre of Finland Ltd. also shows that a 100 percent renewable system (100% RE) is the cheapest electricity production option and can be achieved with very little energy storage. "South America has a unique renewable energy resource base since one of the best wind sites globally is in Patagonia, the best solar energy sites are in the...
When OSHA Visits--Part 2
Continuing Our Guide for New Plant Safety Managers On Monday, we took a closer look at the first few steps of an on-site OSHA visit, including the opening conference and records review. (Refresh your memory on that post here.) As a new plant safety manager, being prepared in a situation like this is key, and we want to make sure you have the tools and information you need. Now let’s take a look at the remaining two portions of the visit—the walk-around inspection and the closing conference. Walk-...
What To Do When OSHA Arrives - Part 1
Continuing Our Guide for New Plant Safety Managers You have been the new plant safety manager for a little over two months. During this timeframe you have had the opportunity to review the limited number of safety procedures left in your office by your predecessor and you are beginning to move forward with your safety responsibilities by following the requirements in the procedures. As part of the Plant Manager’s commitment to safety (our second blog of this series) you have had regularly scheduled...