Keywords: iodine–based polymers, EPR effect, microbeads, radio–opacity, polymeric nanoparticles, drug targeting, tumour tissues, methyl methacrylate, MMA, triiodophenyl acrylate, TIPA, suspension polymerisation, emulsion polymerisation, biocompatibility, tumour detection, tumour imaging, copolymers, cancer, X–ray visibility
Triiodophenyl acrylate–based microbeads find important use in the medical field
Preparation of polymeric micro– and nanoparticles has significantly become an effective approach for achieving efficient drug targeting to tumour tissues. A promising solution could be the use of a radio–opaque polymeric system carrying iodine groups. In this context, radio–opaque polymeric microparticles based on methyl methacrylate (MMA) and an 2,4,6–triiodophenyl acrylate (TIPA) were synthesised by suspension and emulsion polymerisation techniques. Various compositions of p(MMA–co–TIPA) were physico–chemically and biologically characterised through FTIR–ATR, SEM, EDX, in vitro biocompatibility and X–ray measurements. These copolymers exhibit good in vitro cell compatibility together with good X–ray visibility so they are good candidates for tumour detection and imaging.