Annexin A1 is a member of a phospholipid and calcium binding family of proteins; it is involved in anti-inflammation and in the regulation of differentiation, proliferation, and apoptosis. Here, we show the existence of a functional binding site for the tumor suppressor p53 near the proximal CCAAT box and the fact that the basal expression of annexin A1 in human colon adenocarcinoma cells is driven by p53 at the transcriptional level. Posttranscriptional mechanisms may also play an important role in maintaining constitutive annexin A1 expression. In addition, a p53/NF-Y complex is detected bound to the p53 binding site on its promoter. Butyrate is a natural product of fiber degradation in the colon and a key regulator of colonic epithelium homeostasis. We show that butyrate, a class I and II histone deacetylase inhibitor, induces transcriptional activation of annexin A1 expression correlated with differentiation. The effect of butyrate is mediated through a release of NF-Y from the proximal CCAAT box and an enhancement of p53 binding. The interaction of p53 with the promoter is dependent on p38 MAPK activity either in the absence or in the presence of butyrate. Further, activation of p38 MAPK by this agent is required to increase annexin A1 promoter activity and to increase protein expression.
- American Society for Microbiology
- Upregulation of annexin a1 expression by butyrate in human colon ...
Toro Equipment, in “Hecho en Castilla y León”
The Filter Press Draco installed in Fertifluid opens the program “Hecho en Castilla y León” broadcasted on the 12th of JanuaryOne of our equipment, the Filter Press Draco FPA 100/60, is the costar of the program presented by María Nieto. Fertifluid, a fertilizer company placed in Villalar de los Comuneros, is one of the enterprises that star this edition of Hecho en Castilla y León.At the beginning of the report, Roberto González, Technical Director of Fertifluid factory,...
Separate As(V) from solution by mesoporous Y-Al binary oxide: batch experiments
Contaminant arsenic(V) has been regarded as one of the top-priority pollutants to remove from water. In this contribution, different mesoporous Y-Al binary oxides were prepared by the wet impregnation method via varying the molar ratio of Y/Al in the range of 0.029 to 0.116. The manufactured materials were employed as adsorbent to separate arsenic(V) from water. The adsorbent was characterized by N2 adsorption–desorption isotherm, point of zero charge (PZC) and Fourier transform infrared (FT-IR). Furthermore, the...
Green Walls: The New Wall-Y Technical Manual Is Online
The Wall-Y Technical Manual is now available on our website, with updated data and a new graphic design. A useful tool to have all the technical specifications of our product and the prescriptions to correctly design systems for vertical green walls. Wall-Y, the high-strength Geoplast grid, is the ideal solution for creating green walls and for delimiting spaces in gardens or inside buildings. Simple and quick to install, Wall-Y is not afraid of weathering and helps to improve the energy performance of buildings,...
Phosphorus control protects surface waters
Phosphorus is the decisive factor for excessive algae and plant growth in water bodies, that’s why quality standards require reductions in the amount of phosphorus released from wastewater treatment plants into rivers and lakes. In recent years, the outlet limit values have not only been reduced on national levels. Depending on the vulnerability of ecosystems, especially low target values have been defined on regional levels. Examples are regional values for Lake Constance, the Baltic Sea or the Colorado...
TRATAMIENTO DE SOLIDOS Y FLUIDOS POR RADIACION LASER
PATENTE DE INVENCION. Tiene por objeto el tratamiento y desinfección de todo tipo sólidos y fluidos, caracterizada por utilizar generadores láser de emisión en onda pulsada y continua entre los limites de 0,38 a 1000 u, provisto en su cabezal terminal de una lente divergente de seleniuro de zinc (ZnSe), arseniuro de galio (GaAs), fluorita (CaF2), germanio (Ge), cuarzo (SiO2) u otro material similar, de apertura variable a tenor de la superficie a tratar. El principal objetivo es la...