In Québec, Canada, shifts in climate patterns (i.e., rainfall increase) could have consequences on source water quality due to the intensification of surface/groundwater runoff contamination events, leading to a decline in drinking water treatment efficiency and ultimately disinfection by-products (DBPs) formation following treatment. To assess the impacts of climate change (CC) scenarios on DBP formation, a suite of models linking climate to DBPs was used. This study applies three emissions scenarios (B1, A1B and A2) for three 30-year horizons (2020, 2050 and 2080) in order to produce inputs to test several DBP models (total trihalomethanes (TTHMs), haloacetic acids and haloacetonitriles). An annual increase is estimated for all DBPs for each CC scenario and horizon. The highest seasonal increases were estimated for winter for all DBP groups or species. In the worst-case scenario (A2-2080), TTHMs could be affected more particularly during winter (+34.0%), followed by spring (+16.1%) and fall (+4.4%), whereas summer concentrations would remain stable (−0.3 to +0.4%). Potentially, small water utilities applying only a disinfection step could be more affected by rising TTHMs concentrations associated with CC than those having implemented a complete water treatment process (coagulation–flocculation, filtration and disinfection) with +13.6% and +8.2% increases respectively (A2-2080).