Virus and protein separation using Nano alumina fiber media

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Courtesy of Argonide Corporation

Nano alumina fibers, 2 nm in diameter and approximately 0.3 μm long are electroadhesively grafted to a microglass fiber. A non-woven media is formed that has a zeta potential of ~+40 mV at pH 7. The media is capable of high retention of submicron particulates at flow rates up to 160 L/m2/min. The media is manufactured by conventional wet-laid paper making technology. Argonide, the inventor of the technology, manufactures filter cartridges from the media and sells the cartridges under the name NanoCeram. Ahlstrom has an exclusive worldwide license to manufacture and sell the media, and does so under the name Disruptor. The media is proving to be a versatile technology that can be adapted for the purification and separation of biological particles including virus and protein.

The characteristics of the filter media are described as they relate to separation of biological particles. A model was developed that accurately describes the dynamic adsorption of particles within the operating range of pH 5-10. Feasibility was demonstrated of a method of concentrating such particles with enrichment factors of 105 or greater. The reversible adsorption of a mouse serum protein is described. These data suggest several applications for separation and concentration including the use of the media as a thin bed chromatographic separator.

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