Zysense offers unique highly precise instruments in healthcare and specialty gas measurement applications. Our NOA 280i is the global leader in precise nitric oxide measurement and has been used by over 1000 leading hospitals and research institutions around the world. NOA 280i has been the equipment of choice for reliable, reproducible, and robust measurement of nitric oxide in blood, plasma, gases, cell cultures, and other applications. Our exhaled nasal application has been used by researchers to diagnose asthma, primary ciliary diskensia, efficacy of vasodialators, neo-natal research, wound care, and many more. Not just for medical research, the NOA 280i is also widely used in the environmental field to measure agricultural responses to pathogens and diseases, as well as in progressing nutraceutical research into nitric-oxide-producing supplements such as beet and spinach juice.

Company details

#13663 Providence Rd, #371 , Weddington , North Carolina 28104 USA
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Business Type:
Industry Type:
Air Monitoring and Testing
Market Focus:
Globally (various continents)


On June 2016 Zysense acquired the assets of Sievers Nitric Oxide Analyzer NO 280i from General Electric. Zysense principals are experienced in the field of analytical instruments and previously led the General Electric Analytical Instruments division also known as GEAI. Sievers NO 280i was a part of GEAI for over 12 years.


GE Water & Process Technologies, Analytical Instruments

In 2005, the General Electric Company sought to expand its rapidly growing portfolio of water purification offerings by acquiring the Ionics group of companies. The former Ionics Instruments became part of the GE Water & Process Technologies division. Known informally as Zysense LLC, the company now provides a wide range of instrumentation solutions for its traditional markets, while developing and manufacturing measurement technologies for the broader GE Water & Process Technologies group.Water and Process Technologies

Sievers Instruments

Sievers Instruments, Inc. was formed in 1984 by two colleagues from the University of Colorado, Dr. Misha Plam and Professor Robert Sievers. Based on innovative chemiluminescence technology, Sievers Instruments developed a novel detector designed for determination of nitric oxide that has since become the standard for biomedical research into the role of nitric oxide in biological systems. Based on the this core chemiluminescence technology, Sievers subsequently introduced the Sulfur Chemiluminescence Detector (SCD), leading to more than 1,000 SCD instruments installed worldwide for use in a broad range of applications.

Sievers Instrument’s most widely used product line, however, evolved from work done under a NASA contract to develop an instrument to monitor drinking water quality in space. The Model 800 Total Organic Carbon (TOC) Analyzer represented a true breakthrough in TOC analysis. Since its introduction in 1993, the Model 800 technology has grown into a product family that has earned market leadership positions in both semiconductor and pharmaceutical industries.

In January 1997, a Sievers TOC instrument developed for NASA was tested successfully on the Atlantis/Mir space shuttle mission and its successor was subsequently installed on the International Space Station.
Ionics Instruments

By combining the Ionics and Sievers product lines, Ionics Instrument Business Group (Ionics Instruments) was created. In 1999, Ionics further expanded its range of measurement solutions by acquiring Agar Environmental, Ltd. Founded in 1990, Ionics Agar Environmental Ltd. specializes in developing, manufacturing and marketing state-of-the-art environmental protection and process control systems. Leakwise® brand products detect and continuously monitor the presence and changes in very thin layers of contaminating hydrocarbons. With these highly sensitive and robust environmental monitoring technologies, Ionics Instrument’s range of products and solutions have expanded out of the laboratory and factory, into the very locations that present the most difficult measurement problems.