Acute Toxicity Testing Articles
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Toxicological Evaluation, Physical, and Chemical Tests for Cosmetics
Cosmetics play a significant role in our daily lives, with millions of people using them to enhance their appearance or maintain their skincare routine. However, the safety of these products should always be a top priority. To ensure the safety and quality of cosmetics, thorough toxicological evaluation, and physical and chemical testing are crucial steps in the development and manufacturing ...
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Navigating EU and UK Classification Divergence
As the UK bid farewell to the EU on January 31, 2020, regulatory shifts set in motion a unique challenge – the divergence between the EU’s Harmonised Classification and Labelling List (C&L) and the UK’s Mandatory Classification List (MCL). While this divergence touches various sectors, we focus on the fragranced goods industry. A bottle of perfume, a scented candle, or an ...
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A Quick Guide to CLP Pictograms
The CLP (Classification, Labelling and Packaging) pictograms are essential for communicating information about the hazardous properties of a substance or mixture. This article will provide an overview of these pictograms and explain how they are used in hazard communication. The CLP Regulation is a legal requirement for all substances and mixtures sold within the European Union (EU). This ...
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CLP Hazard Warning Symbol: Skull and Crossbones Pictogram
In this blog, we will delve into the significance of the skull and crossbones pictogram and explore the safety measures that should be taken when dealing with products that bear this emblem, denoting acute toxicity. We will discuss the potential risks associated with acutely toxic substances and provide practical tips on how to store products featuring the skull and crossbones pictogram to ...
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BetaGlue published an article on the performance and safety of BAT-90 on ‘In Vivo’
According to the article featured in the international peer-reviewed journal, BAT-90 could be considered a safe and innovative therapeutic option for unresectable solid liver tumors BetaGlue Technology’s Antonino Amato and Pier Luigi Carriero, together with Gordon McVie (King’s College London), Giovanni Paganelli (Istituto Romagnolo Studio Tumori, IRCCS), Roberto Cianni and ...
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Summary and Schemes of Sludge Drying Technology
#sewagesludgedewatering #activatedsludgesewagetreatment Due to the high output, high moisture content and huge volume of sludge in the increasingly large-scale sewage treatment plant, it is not only inconvenient in the process of storage, transportation, loading and unloading, but also has high potential environmental safety risks and hidden dangers. The cost of sludge disposal in some ...
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iTOXcontrol safeguards intake Romanian drinking water (Toxcontrol)
The Romanian water supply company Apavital has installed a monitoring station to safeguard the intake of water from the river Prut. The monitoring station is part of an integrated monitoring that signals sudden changes in the water quality of the rivers, enabling Apavital to take appropriate measures, in the worst case a stop of the intake. The iTOXcontrol is developed by the Dutch company ...
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`Dry` and `liquid` chitosan in stormwater treatment.
Disclaimers: – This post offers my view on the topic based on my review of scientific literature and manufacturer’s documentation available online as well as my own hands-on experience with chitosan and other chemicals in water treatment. – Links to third party websites in this post are not to be considered as my endorsement of their products. What is chitosan? Chitosan, a ...
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Using Chemcatcher in the Safe Removal of World War II weapons in North and Baltic Seas - Case Study
Since the aftermath of World War I and II, the North and Baltic Seas have been littered with thousands of ship and aircraft wrecks, housing a deadly cargo of conventional munition and agents of chemical ...
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QSAR Models for Predicting the Acute Toxicity of Selected Organic Chemicals with Diverse Structures to Aquatic Non-Vertebrates and Humans
Abstract : The linear and non-linear relationships of acute toxicity (as determined on five aquatic non-vertebrates and humans) to molecular structure have been investigated on 38 structurally-diverse chemicals. The compounds selected are the organic chemicals from the 50 priority chemicals prescribed by the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme. The models used for the ...
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Toxicity and Microcystin Content of Extracts from a Planktothrix Bloom and Two Laboratory Strains
Abstract : Toxic effects and microcystin content from various extracts of aPlanktothrix agardhiibloom and two different strains ofPlanktothrix agardhii, HUB 076, and NIVA 34 were investigated. Extracts were obtained with solvents of different polarity such as hexane, dichloromethane, methanol, and water. Additionally, different pre-treatments were used to break the cells before extraction. Acute ...
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The Predictive Potential of a Battery of Ecotoxicological Tests for Human Acute Toxicity, as Evaluated with the First 50 MEIC Chemicals
Abstract : The acute toxicities of the first 50 chemicals (dextropropoxyphene hydrochloride excluded) of the multicentre evaluation of in vitrocytotoxicity (MEIC) programme were determined on four aquatic invertebrates and a bacterial strain (Photobacterium phosphoreumfor the MicrotoxTM test) commonly used in ecotoxicology testing. Three of the aquatic invertebrate tests consisted of cyst-based ...
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Modelling of Human Acute Toxicity from Physicochemical Properties and Non-Vertebrate Acute Toxicity of the 38 Organic Chemicals of the MEIC Priority List by PLS Regression and Neural Network
Abstract :Linear and non-linear modelling of human acute toxicity (as human lethal concentrations; HLCs) of the 38 organic chemicals from the 50 priority compounds of the Multicentre Evaluation ofIn VitroCytotoxicity (MEIC) programme was investigated. The models obtained were derived either from a set of 23 physicochemicals properties of the compounds of from their acute toxicities to five ...
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Bioassays used for Detection of Ecotoxicity at Contaminated Areas
Abstract : Ten bioassays were used for the evaluation of acute, (sub)chronic toxicity and genotoxicity of an unknown soil from a military base and six model soils that were contaminated at former military bases with the major pollutants : kerosene, petroleum and used motor oil. The test species represented algae and higher plants, invertebrates and bacteria. The ability to detect toxicants in ...
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Toxicity Assessment of Chemicals using Conventional Acute Daphnia magna Tests, Toxkits and Fluotox Microbiotests
Abstract : Simple, rapid and cost-effective testing procedures were developed over the last few years, mainly for application in routine toxicity screening. One of the most significant breakthroughs in this regard are the highly standardized Toxkit microbiotests, which make use of dormant or immobilized stages of selected invertebrate species as the biological material from which the test species ...
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Cyst-Based Toxicity Tests. - VI. The Potential of Ecotoxicological Tests for the Predicton of Acute Toxicity in Man as Evaluated on the First 10 Chemicals of the MEIC Programme
Abstract : In the framework of the multicentre evaluation ofin vitrocytotoxicology (MEIC) programme, the first ten chemicals of the prescribed list were tested for acute toxicity in four standardised cyst-based aquatic invertebrate tests, consisting of two rotifer species (the estuarineBrachionus plicatilisand the freshwaterBrachionus calyciflorus) and two crustacean species (the halophilic ...
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Acute Toxicity Bioassays using Rotifers. I. A Test for Brackish and Marine Environments with Brachionus plicatilis
Abstract :A standardized 24-h acute toxicity test for the marine environment using the rotiferBrachionus plicatilisis described. Test animals are obtained by hatching cysts, thus eliminating the need for stock cultures. Since animals hatching from cysts are of similar age, genotype and physiological condition, test variability is greatly reduced. Controlled cyst hatching is achieved by ...
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Comparative Acute Toxicity of the First 50 MEIC Chemicals to Aquatic Non-Vertebrates
Abstract : The acute toxicity data of the first 50 chemicals of the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme is compared for three cyst-based toxicity tests (Artoxkit M with Artemia salina, Streptoxkit F with Streptocephalus proboscideusand Rotoxkit F with Brachionus calyciflorusand two other tests (the Daphnia magnaand the Photobacterium phosphoreumMicrotoxTM tests) ...
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Laboratory Studies with Microbiotests to Evaluate the Acute Toxicity to Aquatic Biota of Herbicides used in Portugese Paddy Fields
Abstract : Rice crops constitute a potential risk of contamination of aquatic ecosystem since the water from paddy fields (which may still contain certain amounts of herbicides used to combat plant pests) is in most cases, discharged directly or indirectly into the surrounding water bodies. In order to evaluate the possible effects of this contamination, laboratory and field work is performed in ...
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The Toxicity Identification of Inorganic Toxicants in Real World Samples
Abstract :The toxicity of a sediment pore water and an effluent was characterized using Toxicity Identification Evaluation (TIE) procedures. Both samples exhibited acute toxicity to the freshwater crustaceanThamnocephalus platyurus. The TIE approach was conducted using an enlarged battery of fractionation tests. Toxicity of the pore water sample was removed or reduced significantly by the cation ...
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