Assays Articles
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IRTA Biosafety Building - Case Study
IRTA has one of the largest and most modern biosafety building level 2 facility in Europe. With more than 500 m2 of surface area and 10 IRTAmar recirculation units where challenge and pathology assays are carried out, developing new vaccines. The plant is equipped with a double system of sterilization and disinfection of the reject water, which guarantees environmental safety. ...
By IRTAmar
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Unveiling the Secrets of Plant Power: A Deep Dive into Plant Vitamin Analysis
Plants, the silent heroes of our planet, are not just culinary delights or decorative ornaments. They are nature's chemical factories, churning out a vast array of bioactive compounds, including essential vitamins. Understanding the vitamin content of plants is crucial not only for human health and nutrition but also for optimizing agricultural practices and promoting sustainable food systems. ...
By Lifeasible
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Cell Immortalization
Creative Bioarray is offering cell immortalization service. Based on our experienced scientist team and elaborate technical platforms, we have been able to successfully immortalize cells from any species and any tissue with the function you need. Our custom immortalization service can significantly extend replicative capacity of your target cells, which saves your time and money over trying by ...
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Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs
Introduction of OligonucleotidesOligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA, anti-gene transcription factor inducers, and nucleic acid aptamers. Oligonucleotide sequences ...
By BOC Sciences
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Advancing Research with miRNA Luciferase Reporter Assay
In the ever-evolving field of molecular biology, scientists are continually exploring the intricate mechanisms that govern gene expression and regulation. Among the various methods used to investigate these processes, the miRNA Luciferase Reporter Assay has emerged as a powerful tool to study the role of microRNAs (miRNAs) in gene regulation. This assay enables researchers to unravel the complex ...
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Study reveals optimal growth temperature for algal toxin
Scientists at the Carnegie Institution for Science have made a significant discovery regarding the temperature conditions that promote the growth of algal toxins. Their research indicates that regions at higher latitudes face a heightened risk of dangerous levels of a common algal toxin called microcystin when the temperature ranges between 20 and 25 degrees Celsius (68 to 77 degrees ...
By LG Sonic
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Illuminating the World of Chemical Fluorescence Probes: Shedding Light on the Unseen
What is the Chemical Fluorescence Probe? Chemical fluorescent probes are chemical instruments that are most commonly used to label antigens or antibodies in fluorescent immunoassays. They can also be used to detect microscopic properties of microenvironments, such as surfactant micelles, bimolecular membranes, and protein active sites. Chemical fluorescent probes have characteristic fluorescence ...
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Colorado Department of Public Health & Environment (CDPHE) - Case Study
The challenge CDPHE needed to replace an existing, outdated LIMS with a system that better met its needs for instrument integration, a customer-facing web portal, and enabled better and more automated reporting. Years later, a second challenge arose due to the increased demand for the lab because of the COVID-19 pandemic, requiring more scalable infrastructure. The Solution The solution ...
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Guide to isothermal titration calorimetry
What is isothermal titration calorimetry? Isothermal titration calorimetry (ITC) is an experimental method used to measure the heat released or consumed in bimolecular chemical reactions. Chemical reactions can be exothermic or heat-consuming, depending on the relative energy stability of the reactants. Isothermal titration calorimetry can be used to quantify the magnitude of the heat change ...
By Profacgen
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Advancing Research with miRNA Luciferase Reporter Assay
In the ever-evolving field of molecular biology, scientists are continually exploring the intricate mechanisms that govern gene expression and regulation. Among the various methods used to investigate these processes, the miRNA Luciferase Reporter Assay has emerged as a powerful tool to study the role of microRNAs (miRNAs) in gene regulation. This assay enables researchers to unravel the complex ...
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Pharmaceutical Analysis: Unveiling the Power of Chromatographic Techniques
Pharmaceutical analysis is a form of using all chemical, physical, biological, microbial and other means and methods to study the chemical properties of drugs. During the testing process, the stability of the drug itself, biological components and clinical drug use must be considered. With the continuous development of high technology, the rapid analysis and detection technology of modern drugs ...
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Quantitative Analysis of ADC Components - Ligand Binding Assay (LBA) and LC-MS/MS
There are both large and small ADC molecules. A variety of biological analysis methods and platforms are needed to analyze the diversity of ADCs. Conventional LC-MS/MS small-molecule assays are often used to analyze uncoupled payloads and DAR distributions over time, while ligand binding assays (LBA) and LC-MS/MS can also be used to analyze total antibodies (TAb) and total ADCs. The choice of ...
By BOC Sciences
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Fragment Hit Identification in FBDD
In the field of fragment-based drug discovery (FBDD), biophysical methods such as NMR, native MS, high-concentration biochemical screens (HCS), thermal shift assays (TSA), or surface plasmon resonance (SPR) are usually used as pre-screening techniques to screen fragment libraries to identify the most promising binders. However, employing a subsequent cascade of these methods prior to X-ray ...
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X-Ray Crystallography: Protein Sample Requirements
A precondition for a successful crystallographic screening is a pure, stable, and monodisperse protein sample. In the process of protein production, controls such as SDS-gels already indicate towards the purity of a protein sample. Additionally, during standard concentration determination via UV/VIS, contamination by DNA or RNA can be assessed. In the following section, typical methods for ...
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Data Management Infrastructure - Case Study
We developed a centralised infrastructure for recording, storing, and querying private and public transcriptLife Science Data, and a meta-analysis app for aggregating differential expression results across ...
By Genestack
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What is the Difference between Luminescence, Photoluminescence, Fluorescence, and Phosphorescence?
The terms; luminescence, photoluminescence, fluorescence and phosphorescence are routinely used in research papers to describe the emission of light from a sample. This multiple naming can be confusing with several of the terms being used interchangeably and researchers from different scientific backgrounds preferring to use one name over another. In this article we answer the question, “What is ...
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Overview of Brucella Abortus
Brucellosis is a zoonotic infectious disease caused by Brucella, and it is one of the most widespread zoonotic diseases in the world, which brings great losses to the animal husbandry industry. Here, we will outline several aspects about the pathogen, living environment, identification, and diagnostic procedures of Brucella, hoping to popularize knowledge about brucellosis. Characteristics of ...
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Surfaced Enhanced Raman Scattering (SERS)
Introduction Surfaced enhanced Raman spectroscopy, (SERS), is an enhancement technique used to overcome the challenges seen with weak Raman scattering. SERS provides all the advantages of Raman spectroscopy whilst also offering higher sensitivity thorough scattering enhancement and fluorescence quenching. SERS can increase the Raman signal by up to 1010-15, allowing the analysis of single ...
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How Oxygen Sensing Technology Can Deliver Faster Test Results For Food And Beverage Microbiology
Oculer Ltd, Ballina, Ireland1 and School of Chemistry and Chemical Engineering, Queens University, Belfast, UK2 Why use O2 sensors? O2 sensors are widely used in many areas of biology and they have been applied for monitoring the activity and growth of bacteria in the environment. There are a small number of reports of their use for the specific detection of microbial growth in the laboratory. A ...
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Automated Yeast And Mould Detection In Less Than 48 Hours
Widely used in the dairy industry for the detection of yeast and mould in finished products, particularly yoghurt, the Oculer Rapid 930 Series Y&M assay can deliver automated results within 48 hours without the need for specific microbiological expertise. The Oculer Series 930 system uses sensitive oxygen sensors to detect the growth of yeast and moulds in a proprietary selective medium ...
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