in vitro toxicity Articles
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In vitro intracellular trafficking of biodegradable nanoparticles dextran-spermine in cancer cell lines
The objective of the present study is to evaluate the effect of cationic dextran on the proliferation rate and biosynthetic activities of HT29, a human colonic adenocarcinoma, and MCF7, a human breast cancer cell line. Cationic dextran was prepared by means of reductive-amination between oxidised dextran and the natural oligoamine, spermine. Biological evaluations including cell proliferation ...
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Rapid differentiation of in vitro cellular responses to toxic chemicals by using MALDI‐TOF mass spectrometry
Changes in protein expression as a cellular response to chemical exposure have been well established. Current methods for monitoring cellular responses usually require the use of specific reagents and/or labor‐intensive procedure. In this study, the concept on using mass spectral pattern to distinguish different cellular responses is demonstrated. The concept is based on the ability to acquire ...
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How SEKISUI XenoTech ensures quality and productivity with the MVS - Case Study
Delivering high-quality data to fast-moving pharma and biotech clients can be challenging. To ensure productivity while meeting stringent quality goals for their clients, XenoTech turns to the MVS. Results within 20% of 1 standard deviation To ensure that their automated liquid handlers meet strict specifications so that assay results from replicates stay within 20% of one standard deviation, ...
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Toxicological and biological effects of nanomaterials
In this paper, we summarise the most recent findings on the toxicological and biological (including both favourable and adverse) effects of some studied nanomaterials (nanotubes, fullerene, metallofullerenes, their derivatives, and metallic nanoparticles). The dose-dependent, nanosize dependent, nano-structure dependent biological activity in particular nanotoxicity are discussed. Results show ...
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