Ion Chromatography Articles
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Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs
Introduction of OligonucleotidesOligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA, anti-gene transcription factor inducers, and nucleic acid aptamers. Oligonucleotide sequences ...
By BOC Sciences
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Techniques for Chromatography Testing and Mass Spectrometry
Chromatography testing and mass spectrometry are two analytical techniques widely used in scientific research, pharmaceuticals, food safety, environmental analysis, and forensic investigations. These techniques play a crucial role in identifying and quantifying chemical compounds, determining the purity of substances, and understanding molecular structures. In this article, we will explore the ...
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Polymer Characterization: A Practical Guide
What is polymer characterization? The study of the physical, chemical, and mechanical properties of polymers is known as polymer characterization. It is a broad field that includes a variety of techniques. The goal of polymer characterization is to comprehend polymer structure-property relationships. This knowledge can be applied to create new polymers with desired properties, improve the ...
By Matexcel
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Drug-to-Antibody Ratio Analysis Methods
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody drug conjugates (ADCs). Over the years, several ADC bioanalytical methods have been developed to better estimate these properties for early development and routine quality control applications. In this article, we provide an overview of the most widely used methods for the detailed analysis of DAR ...
By BOC Sciences
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Six Liquid Chromatography Detectors That Analytical Researchers Should Know
Pharmaceutical analysis is the application of analytical chemistry in pharmacy. It is a "method science" for the research and development of drug quality control. It mainly uses chemical, physical-chemical, or biochemical methods and techniques to study chemical structures that have been clarified. UV-Vis Absorption Detector Ultraviolet-visible detector (UVD) is one of the most widely used ...
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SCION Compass Chromatography Data System CDS Overview
A Chromatography Data System (CDS) plays a pivotal role in instrument control, data processing, report generation and data archiving. It is essential for Chromatographic Analysis, including high-performance liquid chromatography (HPLC), gas chromatography (GC), ion chromatography (IC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE), ultra-high performance liquid ...
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High Performance Liquid Chromatography (HPLC) and Pharmaceutical Analysis
High performance liquid chromatography (HPLC) has become an essential technique in pharmaceutical analysis for the separation, identification, and quantification of pharmaceuticals. Due to its high resolution and sensitivity, it is used for testing drug purity, monitoring degradation, studying pharmacokinetics, and examining drug stability. With recent advances in instrumentation, the technique ...
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Monitoring PFAS in water sources
Non-targeted adsorbable organically bound fluorine (AOF) analysis by CIC Per- and polyfluorinated alkyl substances (PFASs) are thousands of organic molecules in which all the hydrogen atoms on at least one carbon are replaced by fluorine [1]. PFASs are widely used in different industries, e.g., as surfactants for film-forming foams or as impregnating agents for packaging [2]. Due to ...
By Metrohm AG
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Simple determination of haloacetic acids (HAAs) in potable water with ion chromatography hyphenated to mass spectrometry
Haloacetic acids (HAAs) are commonly produced as disinfection byproducts (DBPs) from water treatment processes. Some HAAs are regulated by the author- ities and have been classified as potentially carcino- genic. They have traditionally been analyzed by gas chromatography (GC), a technique that requires time-consuming sample extraction and derivatiza- tion, leading to higher costs per analysis. ...
By Metrohm AG
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Fast analysis of AOX in waters by CIC
Measurement of AOCl, AOBr, AOI, and AOF according to DIN 38409-59 AOX (adsorbable organically bound halogens) is a complex parameter covering the sum of halogenated organic compounds adsorbable on activated carbon. Many of these organohalogens and their degradation products pose serious risks to human health and the environment [1–4]. Monitoring them is essential to ensure appropriate ...
By Metrohm AG
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Fast assessment of adsorbable organically bound halogens (AOX) in waters
Determination of AOCl, AOBr, AOI, and AOF with combustion ion chromatography (CIC) according to DIN 38409-59 Adsorbable organically bound halogens (known as AOX) are the sum of numerous halogenated organic compounds that are adsorbable on activated carbon. Many of these organic halogen compounds and their degradation products pose serious risks to human health and the environment. ...
By Metrohm AG
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Fast screening for adsorbable organically bound halogens
Metrohm Combustion IC – a validated all-in-one solution for comprehensive AOX determination (AOF, AOCl, AOBr, AOI) according to DIN 38409-59 Organohalogen compounds are widespread, persistent, and potentially toxic for humans and the environment. However, the techniques commonly used to monitor adsorbable organic halogens (AOX) can only determine the sum of organically bound chlorine, ...
By Metrohm AG
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Coping with the daily challenges of routine water analysis
Analyzing different types of water samples on a regular basis presents several challenges for analysts. Depending on the type of lab (e.g., municipal or water bottling facilities), the number of samples to be analyzed can vary significantly. Every day such laboratories receive hundreds of samples that must go through pH, conductivity, and alkalinity testing, among others. If additional tests ...
By Metrohm AG
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Analyzing halogenated organic compounds with CIC according to DIN 38409-59
What is it that makes your clothing repel water or your cookware have nonstick properties? The answer could be the use of per- and polyfluorinated alkyl substances (PFASs) to coat these materials. This blog article explains how PFASs and other halogenated organic compounds have been used over the past several decades, their effects on our health and the environment, and how to monitor and ...
By Metrohm AG
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Application of LC-MS in the Bioassay of Oligonucleotide Drugs
Introduction of oligonucleotide drugs Oligonucleotides are a class of nucleic acid molecules consisting of dozens of nucleotides with short sequences. They mainly inhibit the expression of target proteins through gene silencing so as to achieve the purpose of treating diseases. The world's first antisense nucleic acid drug was approved in 1998, which started the journey of oligonucleotide drug ...
By BOC Sciences
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Polyacrylate Nanoparticles You Don’t Want to Miss
What are polyacrylates nanoparticles? Polyacrylates are an important class of soft, tough and rubbery polymers, which are known for their high transparency, good impact toughness and elasticity. Polyacrylates and their copolymers are one of the polymeric nanoparticles (NPs). Polymeric nanoparticles are particles within the size range from 1 to 1000 nm and can be loaded with active compounds ...
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History of Metrohm IC - Part 6
Even though combustion ion chromatography (CIC) is regarded as an up-and-coming sample preparation and analysis technique, the basic process behind CIC has already existed for many years. This blog post introduces the history of this technique, the working principle, and some applications for CIC.\r\n"}}">Even though combustion ion chromatography (CIC) is regarded as an up-and-coming sample ...
By Metrohm AG
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Understanding the EPA’s Strategic Roadmap to Address PFAS Pollution
The concern about polyfluoroalkyl substances (PFAS) in drinking water and the environment has grown in recent years. These forever chemicals are the latest target of the EPA’s attention. Supported by funds made available in the 2021 Infrastructure Investment and Jobs Act, the agency has released a strategic roadmap for addressing these chemicals. ...
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Polyacrylate Nanoparticles You Don't Want to Miss
What are polyacrylates nanoparticles? Polyacrylates are an important class of soft, tough and rubbery polymers, which are known for their high transparency, good impact toughness and elasticity. Polyacrylates and their copolymers are one of the polymeric nanoparticles (NPs). Polymeric nanoparticles are particles within the size range from 1 to 1000 nm and can be loaded with active compounds ...
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Best practice for separation columns in ion chromatography (IC) - Part 3
This is the third and final post in our series providing you with tips and tricks on the proper use of ion chromatography columns. In the first part, we mostly discussed the standard operation conditions as well as operational limits for columns, while in the second post, we focused on application related topics and what elution parameters can be changed to modify the separation performance. In ...
By Metrohm AG
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