ACD/Labs’ 1st Annual PhysChem Symposium Opens Frank Discussions on Important, Underdeveloped Areas of Scientific Research


Toronto, Canada (June 1, 2005) - Advanced Chemistry Development, Inc., (ACD/Labs) is pleased to recap on the success of their 1st Annual PhysChem Symposium: Early ADME and Medicinal Chemistry, which was held on October 21, 2004, at Hotel Le Parc in Obernai, France.

This one day symposium was aimed at providing mechanistic insight into the relationship between physical organic properties of drug candidates and their pharmacokinetics through contributed talks and panel discussions, hosted by a distinguished speaker panel of leaders in academic and industrial drug discovery research.

Dr. Antony Williams, Chief Science Officer at ACD/Labs, stated, “ACD/Labs is presently at the forefront of physicochemical property prediction and in the past few months has expanded our efforts into property-based drug design with the introduction of ACD/MedChem Advisor. One advantage of being in the lead is that it exposes us to be further pushed, challenged, and motivated by leaders in the industry. Gathering together over 30 European scientists to celebrate and challenge our approaches enabled us to validate that our present vision is appropriate. We are presently focused on executing on these goals. We acknowledge all attendees and speakers for their insights, contributions, and support.”

Prof. Michael Abraham from University College London, and Dr. Klara Valko from GlaxoSmithKline, were two of the notable speakers present at the event, which facilitated discussions on the vital questions currently at the forefront of drug discovery research.

Dr. Klara Valko opened the day's discussions with his session on the Role of Lipophilicity and Acid/Base Character in Drug Disposition ‘in vivo', and commented on the relationships between calculated log P /log D values and the HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partition. It was pointed out that the presence of positive and negative charges at physiological pH significantly influences compounds' in vivo distribution, and models for predicting human volume of distribution based on measured and calculated physicochemical data were compared.

Professor Michael Abraham gave a presentation titled ‘Can We Identify Models for Brain Uptake and Intestinal Absorption?' as well as a short talk on recent work on skin permeability. Professor Abraham commented on the success of the PhysChem symposium, and on the very friendly atmosphere and extended time scale, which facilitated a considerable discussion between speakers and delegates during the meeting.

The 2nd Annual PhysChem Symposium will be held in Obernai on October 20th, 2005, in conjunction with ACD/Labs' 6th Annual European Users Meeting. Details will be posted at

About Advanced Chemistry Development
Advanced Chemistry Development, Inc., (ACD/Labs) is a chemistry software company offering solutions that truly integrate chemical structures with analytical chemistry information to produce ChemAnalytics ® . ACD/Labs creates innovative software packages that aid chemical research scientists worldwide with spectroscopic validation of structures, elucidation of unknown substances, chromatographic separation, medicinal chemistry, preformulation of novel drug agents, systematic nomenclature generation, and chemical patenting and publication. Combined, ACD/Labs' solutions create an analytical informatics system that provides dramatic feed-forward effects on the chemical and pharmaceutical research process. Founded in 1993, and headquartered in Toronto, Canada, ACD/Labs employs a team of over 100 dedicated individuals whose continual efforts carry ACD/Labs' innovative technologies into pharmaceutical, biotech, chemical, and materials companies throughout the world. Information about Advanced Chemistry Development and its products can be found at

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