European Commission, JRC, Directorate F - Health, Consumers and Reference Materials

Certified reference material for chloramphenicol (CAP) in meat


JRC-IRMM has released a new reference material which will enable food testing laboratories to reliably detect and quantify chloramphenicol in meat at sub µg/kg concentrations.

 Chloramphenicol is a broad-spectrum antibiotic and highly effective against many pathogenic bacteria. Chloramphenicol in humans, however, can cause serious haemotoxic effects. Therefore, the use of chloramphenicol for treatment of food-producing animals was prohibited in the EU (Commission Regulation (EC) No 1430/94). Moreover, Commission Decision 2003/181/EC fixed a minimum required performance limit (MRPL) of 0.3 µg/kg for residues of chloramphenicol in different food matrices, including meat, egg, milk, aquaculture products, and honey.

 ERM-BB130 complements the current chloramphenicol material BCR-445. ERM-BB130 is an incurred pork muscle material with a certified chloramphenicol mass fraction of 0.230 ± 0.021 µg/kg. The reference material is intended to be used for method validation purposes (trueness estimation) and method performance control, and thereby enables laboratories to verify whether their methods comply with the MRPL. The certified value is based on an inter-laboratory characterisation study, and the uncertainty value contains contributions from the characterisation study as well as from the homogeneity and stability assessment. The material has been processed and certified in accordance to ISO Guides 34 and 35. Details about material processing and certification are described in detail in the certification report.

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