The prevalence of per- and polyfluorinated alkyl substances (PFASs) and other perfluorinated compounds (PFCs) in our environment and bodies is a growing concern. Traditional targeted analysis methods are expensive, time-consuming, and require extensive instrumentation. A simpler and faster approach is measuring the sum of all adsorbable fluorine in waters (AOF) for initial screening, followed by targeted analyses of individual PFASs if indicated by higher AOF concentrations. Stay ahead of PFAS and PFC monitoring with this cost-effective and sensitive solution.