AB SCIEX

- ION Mobility Spectrometers

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ION Mobility Spectrometers For research use only. Not for use in diagnostic procedures. The SCIEX SelexION device is an innovative achievement in differential ion mobility spectrometry. This differential ion mobility spectrometry tool has the reproducibility, robustness, and ease-of-use to deliver easy, highly-selective, quantitative and qualitative analyses. The SelexION devise is compatible with UHPLC time scales over multiple MRM transitions simultaneously on several Sciex triple quadrupole, QTRAP™ and Triple TOF™ platforms.

For scientists who are challenged by assays with isobaric interferences and difficult-to-separate, co-eluting contaminants, this fast, reproducible, and easy-to-use approach will enhance the selectivity of your LC/MS/MS separations.

SelexION Differential Ion Mobility Technology takes the some of the world's most advanced mass spectrometry systems and adds a new dimension of selectivity to enhance quantitative and qualitative performance.

The SCIEX SelexION Device is an innovative achievement in differential ion mobility spectrometry. The SelexION Ion Mobility Spectrometry Tool has the reproducibility, robustness, and ease-of-use to deliver highly-selective, quantitative and qualitative analyses; the SelexION is compatible with UHPLC time scales over multiple MRM transitions simultaneously – one of the world's most sensitive triple quadrupole instruments and QTRAP Platforms.

For scientists who are challenged by assays with isobaric interferences and difficult-to-separate, co-eluting contaminants, this fast, reproducible, and easy-to-use approach will enhance the selectivity of your LC/MS/MS separations.

SelexION Technology takes one of the world's most sensitive triple quadropole instrument and the QTRAP System and adds a new dimension of selectivity to enhance quantitative and qualitative performance.

  • Scan Speed
  • Tuning Stability
  • Integrated Chemical Modifier Mounting and Dismounting
  • Scheduled MRM7- Algorithm Support
  • Reproducibility & Robustness
  • Reproducibility & Robustness

  • The device can acquire data for a single MRM transition in 25 msec, including the inter-scan pause time of 20 msec. Four-fold faster than cylindrical ion mobility. Amenable to multiple analyte analysis and UHPLC time scales.
  • The optimum compensation voltage (COV) does not shift by more than 10% of the DMS peak width (full width at half height, typically 2.5V) at a fixed separation voltage (SV) over 24 hours on an equilibrated system operating under standard DMS resolution gas setting. Suitable for quantitative/regulated lab applications.
  • Can increases the ion mobility separation power by up to 10-fold.
  • User mountable and dismountable without the need for tools or breaking vacuum. Compact design takes less than two minutes to install or remove at room temperature.
  • Compatible with the Scheduled MRM'Algorithm that provides automatic, dynamic adjustment of MRM transitions during acquisition, such that only compounds that elute within a specified time window are monitored, allowing the system to dynamically schedule MRM scans during the experiment
  • Proven to meet regulated bioanalysis guidelines.
    Injection of clenbuterol at 5 pg/uL in urine, (a) High chemical noise makes detection impossible, (b) Differential ion mobility spectrometry with SelexlON*' Technology increases selectivity and eliminates the high background, producing a 10-fold improvement in signal-to-noise.
  • Stable-isotope-labeled synthetic peptides generated for quantitation of a therapeutic igG in digested human plasma showed much cleaner MRM signals at the same on-column amount when an ion mobility separation was performed. This yielded a five-fold improvement in the LLOO that was achieved on-column.
  • Significantly reduce and eliminate isobaric intereferences and co-eluting contaminants. Grapefruit extract fortified with conazole degradant products at 0.01 mg/kg. Samples were kindly supplied by R.Schoening, Bayer CropScience. Monheim. Germany and JJasak, Technical University, institute of Food Chemistry. Dresden. Germany.
  • Improving quantitation by reducing structurally-similar interferences. A 30 uL injection of eicosanoids standard mix containing prostaglandin F2a (PGF2a). (a) Interference with structurally-similar species leads to difficulties in identification and quantitation, (b) SelexlON' Technology eliminates isobaric interferences and chemical background.

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