RotaChrom - CPC Cells
RotaChrom designed its top performing CPC cells through Computed Fluid Dynamic simulation software. After thousands of simulations, this tool revealed the drawbacks of conventional CPC cell designs and enabled RotaChrom to create unique and scalable cell design.
Products Details
Drawbacks of Conventional Cell Designs as Revealed by Simulations and Flow Visualizations:
- Circular motion of liquid inside of conventional cells causes back mixing
- Shorter cells, with less surface area, provide less space for separation to occur
- Scale-up of conventional cells are problematic. Flow dynamics drastically changed during scale-up
- Plate-number and stationary phase retention suffered due to bad flow dynamics
It is VERY difficult to ensure cleaning validation of conventional cell designs, as the rotor must be disassembled using hydraulic press, making simple and fast maintenance and cleaning almost impossible.
Advantages of RotaChrom’s Cell Design:
- Injection plug: responsible for the even injection of mobile phase into the stationary phase.
- Tubular cell wall with filling: The circular cross-section not only enables:
- Scalability: Allowing direct scale up from ~5 kg/month (rCPC) to hundreds of kg/month (iCPC-M)
- Convenient Maintenance and Cleaning
- Swab-probing eliminates issues with CPC cleaning validation and GMP regulatory compliance
- Collection plug: Our design increases the solvent retention, which increases loading capacity and chromatographic resolution by 20% for the same column size. Finally, one of RotaChrom’s most impactful discoveries was that our extraction cells can be scaled from 10 mm to 100 mm without impacting performance and increasing flows from mL/mins to multiple L/mins. Furthermore, our unique rotor design allows for these cell sizes to be interchangeable on the same machine. Industrial Scale Centrifugal Partition Chromatography is proven to be superior to conventional preparative chromatographic techniques in terms of precision performance, adaptability, scale up and cost effectiveness.
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