BIOVET

- Water Soluble Granules

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Tylosin is a macrolide antibiotic produced by a strain of Stfeptomyces ffadiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible microorganisms. The tylosin spectrum of activity includes Gram-positive bacteria, some Gram-negative strains, such as Posteufella, and Mycoplasma spp. In most species peak plasma concentrations have been attained 1 to 2 hours after administration of tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed. Tylosin was extensively metabolised. Most of the residues are excreted in faeces predominantly consisting of tylosin A, tylosin factor D and dihydrodesmycosin.

INDICATIONS
The presence of the clinical disease in the herd/flock should be established before preventive treatment is started.
Pigs: Treatment and prevention of Porcine Intestinal Adenomatosis (Ileitis) associatec with Lawsonia intfacellularis. Treatment and prevention of Enzootic Pneumonia caused b\ Mycoplasma hyopneumoniae and Mycoplasma hyofhinis.
Calves: Treatment and prevention of Pneumonia, caused by Mycoplasma spp.
Chickens (Broilers - pullets): Treatment and prevention of Chronic Respiratory Diseases (CRD] caused by Mycoplasma gallisepticum and Mycoplasma synoviae. Treatment and prevention o necrotic enteritis caused by Clostridium pefffingens.
Turkeys: Treatment and prevention of infectious sinusitis caused by Mycoplasmc gallisepticum.


CONTRAINDICATIONS
Do not use in animals with known hypersensitivity to tylosin or other macrolides. Do not use ir cases with known resistance to tylosin or cross-resistance to other macrolides (MLS-resistance) Do not use in animals vaccinated with tylosin-sensitive vaccines either at the same time 01 within 1 week previously Do not use in animals with hepatic disorders.

MODE OF ADMINISTRATION
Orally, through the drinking water, milk or milk-replacer. For the preparation of the medicatec water/milk/milk-replacer the body weight of the animals to be treated and their actual dail^ consumption should be taken into account. Consumption may vary depending on factors like aqe, state of health, breed, husbandry system.

TARGET SPECIES
Pigs, chickens (broilers, pullets), turkeys and calves.


DOSAGE
Oral administration through the drinking water, milk or milk-replacer. 1.1 gram of the veterinary medicinal product corresponds to 1 gram of tylosin. The dosages are as follows: Calves: 10-20 mg tylosin per kg BW (corresponding to 11-22 mg of the veterinary medicinal product per kg BW), twice daily (= daily dose of 20-40 mg tylosin per kg BW), for 7 to 14 days.Turkeys: 75-100 mg tylosin per kg BW per day (corresponding to 82.5-110 mg of the veterinary medicinal product per kg BW) for 3-5 days. Chickens (Broilers, pullets): For the treatment of chronic respiratory disease: 75-100 mg tylosin per kg BW per day (corresponding to 82.5-110 mg of the veterinary medicinal product per kg BW) for 3-5 days. For the treatment of Necrotic Enteritis: 20 mg tylosin per kg BW per day (corresponding to 22 mg of the veterinary medicinal product) for 3 days. Pigs: For the treatment of Enzootic Pneumonia: 20 mg tylosin per kg BW per day (corresponding to 22 mg of the veterinary medicinal product per kg BW) for 10 days. For the treatment of ileitis or PIA: 5-10 mg tylosin per kg BW per day (corresponding to 5.5-11 mg of the veterinary medicinal product per kg BW) for 7 days. To provide the required amount of active substance in mg per litre drinking water/milk/milk-replacer the following calculation should be made:

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