Genotoxicity Test Services
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Manufactured by Molecular Biology Resources, Inc.based in USA
MBR offers assay services to investigate the effects of drug compounds on key DNA replication and repair enzymes, such as human DNA polymerase α (alpha), human DNA polymerase β (beta), human DNA polymerase γ (gamma), and HeLa cell extracts (containing replication protein ...
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Manufactured by Environmental Bio-Detection Products Inc. (EBPI)based in CANADA
In addition to the specific mutagenicity assays provided by EBPI Analytics, a line of general genotoxicity tests are offered. These assays use modified bacteria that have the induction of a SOS DNA response gene coupled to a gene that expresses a measurable colorimetric endpoint. The degree of induction of the SOS response can be ...
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Manufactured by CD Formulationbased in USA
Genotoxic Impurities Test: The control of genotoxic impurities is a complex and delicate project throughout the whole life cycle of drug development, and an important part of it is the assessment of genotoxic impurities. The study of genotoxic impurities involves a combination of organic chemistry, biochemistry, ...
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Manufactured by Gentronix Ltdbased in UNITED KINGDOM
The in vitro micronucleus test (MNT) is a main-stay of most regulatory genotoxicity testing strategies, and is used to detect in vitro clastogens and aneugens. In this regard it complements the Ames test well, as between the two study types they detect all of the three major classes of genotoxin. Fluorescence In Situ ...
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Manufactured by Gentronix Ltdbased in UNITED KINGDOM
The mouse lymphoma assay is one of the mammalian gene mutation assays available and is frequently utilised in most genotoxicity testing regulatory frameworks. Able to detect point mutations, clastogens, and in some cases aneugens; the mouse lymphoma assay has an advantage compared to the HPRT (the alternative mammalian gene mutation assay) ...
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Manufactured by Creative Bioarraybased in USA
extended to metabolite profiling and give out more information about the metabolism of your compound. S9 stability assay and hepatocyte stability assay are also available at Creative Bioarray. Liver S9 fraction (Cat. CSC-C4093X) as a product can be used in genotoxicity tests such as the Ames test as a metabolic ...
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Manufactured by Gentronix Ltdbased in UNITED KINGDOM
The Ames test, a bacterial reverse mutation assay, is the most commonly requested genotoxicity study in regulatory testing frameworks and has been in use for decades. The test investigates the ability of test substances to cause specific mutations in Salmonella or E. coli strains that allow them to then grow on ...
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