Mauna Kea Technologies
Microscope System for Peripheral Nerve Imaging - Monitoring and Testing - Laboratory Equipment
Use Cellvizio Lab to perform longitudinal studies on the peripheral nervous system.
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In vivo imaging of degenerating axons and neuromuscular synapses
- small skin incision is made to expose the tibial nerve and the adjacent gastrocnemius muscle
- intramuscular axons and motor nerve terminals in an innervated thy1.2-YFP16 mouse gastrocnemius muscle with an intact sciatic nerve.
- Axons in the tibial nerve of thy1.2-YFP16 mice all degenerated by 3 days after section of the sciatic nerve, in contrast to the extensive axonal protection seen in WldS mouse nerves.
- Axotomized tibial nerve axons are also preserved 3 days after sciatic nerve section in thy1.2-YFP16-WldS heterozygotes
- Intact NMJs in the gastrocnemius muscle of a WldS homozygote were observable 3 days after sciatic nerve injury but,
- No intact NMJs were ever seen in thy1.2-YFP/WldS heterozygotes at this time point.
Article reference: Axonal and neuromuscular synaptic phenotypes in WldS, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy. Molecular and Cellular Neuroscience, 10.1016/j.mcn.2009.08.002
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