Advanced Electrophoresis Solutions Ltd. (AES) products

In response to the tremendous and urgent needs for the identification of protein charge variants, Advanced Electrophoresis Solutions Ltd. has developed the CEInfinite Automated Preparative iCIEF system.

In the development and production of protein biologics, charge isomers of the target protein can arise due to Post-Translational Modifications (PTMs) and degradation. Biopharmaceutical groups rely on Capillary IsoElectric Focusing (CIEF) and imaged CIEF (iCIEF) to quantify the charge isomers present. Characterizing biologic charge isomers is useful for many life cycle stages including cell line selection, stability studies, formulation, and processing control but this characterization requires the proteins be separated into individual charge fractions with enough purity for downstream assays.

This video was provided by Advanced Electrophoresis solutions focused on our analytical iCIEF configuration. We discuss how this product paired with our innovative carrier ampholyte provides superior separation of your complex drug molecules.