BioDetection Systems (BDS) b.v. products

BDS offers an extensive panel of high-throughput-compatible CALUX^® reporter assays that enable biological effect identification and quantification and effect-based compound detection. Our assays allow for the sensitive and precise detection of specific biological effects at the cellular level. This can be used for the identification of fractions and compounds with beneficial health effects. However, context-dependent repression or overstimulation of these pathways form the key to toxic effects of chemicals. For this, context-dependent thresholds are defined.  In this way this panel can be used to predict major chemically-induced toxic effects such as sensitization, carcinogenesis and mutagenicity and, reproductive toxicity and endocrine disruption, related to health effects like birth- and fertility defects, cancer, metabolic syndrome and obesity.

The results of CALUX assays are typically expressed relative to the activity of a reference compound. We offer concentration series of reference compounds for the CALUX assays, which can be used directly.

We offer several products used for culturing the CALUX cells and performing of the assays, such as trypsin, lysis mix, measuring solutions, FCS and stripped FCS, S9-metabolic enzyme mixtures. Most products we offer are CALUX-tested to ensure low backgrounds and correct functioning in combination with our assays.

BDS offers a variety of products that have been optimized for the use together with our CALUX bioassays. SPE-based water extraction products; protein-binding inhibition (TTR)  columns. Our clean-up columns are optimized for CALUX analysis of dioxins are tailor-made to ensure fast-running, effective clean up with high recovery, easy cleaning ability and robustness. The columns can be delivered along with a robust placeholder both for columns as well as for collection vials for e.g. human samples.