Creative Peptides articles

Synthesis of peptides is a complex process that usually involves different synthesis strategies and techniques. The following are some common approaches to peptide synthesis processes and techniques:

Solid-Phase Synthesis

This is one of the most commonly used methods for peptide synthesis. It is based on

What are cell penetrating peptides?

Cell Penetrating Peptides (CPPs) are short peptides that have the ability to cross biological membranes and enter cells. They are able to traverse the cell membrane by directly translocating across the lipid bilayer or by exploiting endocytic pathways.

CPPs are generally composed of 5-30 amino acids and are known for their high cell-penetrating effi

Peptides are short chains of amino acids that have various biological activities and therapeutic potential. They play crucial roles in various biological processes, such as cell signaling, enzyme activity regulation, and immune response modulation.

Peptide fermentation allows for the production of peptides in sufficient quantities to meet the demands of research, clinical trials, and c

Structure and Properties of PNA

Peptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide backbone, as well as an N-terminus and a C-terminus. The nucleobases embedded in PNAs are the classic adenine (A), guanine (G), cytosine (C), and thymine (T), all of which can also be found in DNA. However, the nucleobases in PNAs are not attached to the conventional deoxyribose or ribose sugar. Instead, they are coupled to an N-(2-aminoethyl) glyci

The major preclinical phases of peptide drug discovery encompass initial target identification and validation, hit identification, high throughput screening, lead optimization, etc. Among them, hit identification is one of the most critical steps in identifying peptides that can interact with well-validated targets.

Hit identification (HI) follows the process of target validation, in which the compound screening assays are developed. The main goal of the HI process is to ap

Peptide plays a key role in basic biochemical and physiological processes, and it is essential to many aspects of biomedical research, especially when the pharmaceutical industry continues to apply new drug candidates in the biological field. Therefore, rapid, efficient, and reliable methodology for the chemical synthesis of peptide drugs is of utmost interest in research.

In general, peptide drugs are chemically synthesized through coupling the carboxyl gr