Eidogen-Sertanty, Inc. software

Eidogen`s algorithm engine for structure determination, binding site annotation, and similarity assessment have been used to generate the largest, most highly integrated database of structural chemogenomics information ever created. Some of the major features of TIP and the corresponding algorithms and software tools responsible for these features are summarized below:

The TIP Web Portal is the backend interface with the TIP database, providing a user-friendly, secure, web-based interface for performing advanced querying and data extraction from the database. With the TIP Web Portal, users are enabled with sophisticated search and sorting tools which allow quick and easy retrieval of relevant structural and binding site information. Once a set of interesting targets is collected, the user exports a TIP Project file to their Windows or Linux desktop for analysis with the client-side tool, the Eidogen Visualization Environment (EVE™).

The EVE™ analysis tool allows users to visualize and compare the small molecule binding sites of targets of interest in a matter of seconds. With EVE`s powerful yet easy-to-use Java3D©-driven interface, both expert and non-expert users alike can quickly analyze and compare important binding site properties and ligand interactions, dramatically enhancing the efficiency with which structure-based selectivity, binding mode analysis, and lead optimization studies can be carried out.

The Target Informatics Platform`s content includes more than 520K high resolution protein structure chains with reliably annotated small molecule binding sites covering every major drug target family including proteases, kinases, phosphatases, phosphodiesterases, nuclear receptors, and GPCRs. In addition to TIP`s high quality structural annotation, it is the only database of its kind that stores all similarity relationships between every sequence, structure, and binding site, making it an incredibly powerful system for structural and comparative proteomics.