Envigo services

Safety Testing Services

Safety studies for a biopharmaceutical aim to define the pharmacologic and toxicologic effects of the drug in animals that are predictive of the human response. Studies aim to: Define safe starting doses / escalation schemes for clinical studies. Identify target organs / tissues for toxicity and reversibility of toxic effects. Identify safety parameters for clinical monitoring. Provide information on mechanism of action and determine the fate of the test compound and how these may relate to toxicity and efficacy.

Bioanalysis Services

Analysis of biopharmaceuticals in biological samples from pre-clinical and clinical studies is an important part of the drug development process. The Bioanalytical division at Huntingdon Life Sciences is an operational grouping responsible for new technologies to assist with drug discovery and development. Knowledge of the pharmacokinetics (PK) of a product in humans and animals is important in choosing dose levels and regimens as well as in assessing safety margins and the relevance of extrapolating toxicological data to humans.