Femtonics products

The FEMTOSmart series of microscopes from Femtonics are sophisticated two-photon imaging systems tailored for advanced in vivo research and diverse biological applications. The series is designed with a movable body that accommodates seamless positioning in X, Y, and Z axes, essential for optimal sample accessibility during experiments. These microscopes support flexible scanning patterns, including resonant and galvo scanning, enabling high-speed calcium imaging and precise control for functional imaging in neuronal networks. Additionally, FEMTOSmart microscopes offer three-photon (3P) imaging capabilities, which provide deeper tissue penetration with enhanced contrast due to the use of longer excitation wavelengths. Researchers can further benefit from the integration of photostimulation techniques with multiple beam paths, allowing precise cellular activation and monitoring. Moreover, the complementary MES and MESc software packages facilitate data analysis, real-time display and extended measurement control, making FEMTOSmart devices versatile tools for cutting-edge research in neurobiology and cellular imaging.

Enhance your in vivo measurements effortlessly with the Femtonics FocusPinner, which offers Real-Time Motion Correction along X,Y and Z (axial) direction, effectively eliminating motion artifacts. Neuroscience relies more heavily on in vivo measurements of neuronal activity to study cognition, memory, CNS diseases, behaviour, neurochemistry, and many other aspects of the field. One of the bottlenecks of in vivo functional measurements is motion artifacts caused by the movement of the animal, respiration, circulation, or any of the numerous other sources. Here we offer a real-time solution for in vivo motion correction which eliminates artifacts caused by heartbeat, breathing or physical activity at over 100 kHz speed allowing calcium and voltage imaging from spines, dendrites, axons and somata with high resolution.

The FemtoStage is a sophisticated motorized XY stage designed to provide exceptional precision in positioning samples during microscopic examination. This unit features a flexible sample holder and is engineered to cater to a diverse range of experimental requirements. The device supports high precision movements, essential for tasks such as in vivo and in vitro experiments, which require meticulous positioning, including patch-clamping, complex behavior testing, and network or voltage imaging. Its adaptable design allows for multiple configurations, accommodating specific user requirements for varied neurobiological applications. With dimensions of 600 × 510 × 73mm and a load capacity of 6kg, the FemtoStage can precisely maneuver with a minimal step size of 50 nm, ensuring reliable, high-precision sample manipulation. This motorized stage is built to support researchers in conducting refined, high-accuracy experiments integral to advanced biological studies.