Gentronix Ltd services

The Ames test, a bacterial reverse mutation assay, is the most commonly requested genotoxicity study in regulatory testing frameworks and has been in use for decades.  The test investigates the ability of test substances to cause specific mutations in Salmonella or E. coli strains that allow them to then grow on selective agar plates.  Used to detect DNA reactive mutagens, which have the potential to be highly potent in vivo, Ames positive results are taken very seriously when assessing safety.