Izon Science Limited products

The Automatic Fraction Collector (AFC) automates extracellular vesicle (EV) isolation and enables precise, customisable and reproducible separation. Whereas EV isolation was previously labour-intensive and difficult to scale, the AFC – together with size exclusion chromatography-based qEV columns – enable EV isolation to be achieved easily and with minimal intervention.

Your automated chromatography system for purifying samples from the qEV2, qEV10, qEV100 and larger customised columns. Quickly identify your ideal purified collection volume (PCV) by running your sample and studying the UV trace to get an elution profile snapshot. Optimise EV isolation with software that displays data on particle peaks, flow rate, pressure, conductivity, pH, and time left in the run until completion. Optimise EV isolation with software that displays data on particle peaks, flow rate, pressure, conductivity, pH, and time left in the run until completion.

Take the next step in scalability with the qEV DXter — our robotic liquid handling system designed for qEV columns. Built for the needs of growing EV diagnostic developers, the DXter automates and accelerates your EV isolation workflow with the power of parallel processing.

Using Tunable Resistive Pulse Sensing (TRPS), the Exoid measures nanoparticles one-by-one as they pass through a tunable nanopore, allowing you to obtain measurements of particle size and concentration, or particle size and zeta potential, on a single-particle basis. Unlike ensemble techniques, where larger particles can skew size measurements, the Exoid provides insightful, high-resolution measurements that allow you to detect important differences in particle size distribution.

Nanopores for Tunable Resistive Pulse Sensing particle characterisation. Nanopores (NP) are conical holes formed in flexible polyurethane membranes, and are used on the Exoid and qNano. Nanopores can be stretched, so that they are an optimal size for the particles being measured.  There are nine nanopore sizes, which cover an analysis range of particles sized11 μm.  Note - NP80s are available by special request only. Please contact your local sales representative if you would like to order this product. We generally recommend using NP100s instead. 

Calibration for Validated Measurements. For accuracy and certainty, all TRPS measurements include a calibration measurement shortly before and/or after a sample is analysed.  A calibrated measurement is a pure comparison of sample parameters with calibration parameters at the same system settings.

Size exclusion chromatography column for efficient extracellular vesicle isolation, suited to 150 µL sample loading volumes of biofluids and cell culture media.

Size exclusion chromatography column for efficient extracellular vesicle isolation, suited to 500 µL sample loading volumes of biofluids and cell culture media.

Size exclusion chromatography column for efficient extracellular vesicle isolation, suited to 1 mL sample loading volumes of biofluids and cell culture media.

Size exclusion chromatography column for efficient extracellular vesicle isolation, suited to 2 mL sample loading volumes of biofluids and cell culture media.