Peptide Modifications & Specialty Peptides
Unnatural / Unusual Amino Acids
Non-natural amino acids are incorporated into peptides for many different reasons. For example, unnatural amino acids are used to increase the activity or selectivity and plasma stability of peptides in drug discovery projects. Another example is the use of non-natural amino acids for the induction or stabilization of secondary structures (helices, sheets, turns).
Isotope Labeled Peptides
Interested in purchasing stable isotope labeled (SIL) peptides? Please hop over to Reference Peptides for Targeted Proteomics - SpikeTides & SpikeMix. Isotope labeled or heavy amino acids are derived from natural amino acids by substitution of atoms with respective heavy isotopes. The most frequent substitutions of non-radioactive amino acids are 12C by 13C, and 14N by 15N, and 1H by 2H (deuterium).
Post-Translational Modifications (PTMs)
Post-translational modifications (PTMs) such as protein phosphorylation, protein methylation or protein acetylation play an important role in virtually all biological processes. Therefore, the synthesis of post-translationally modified peptides (e.g. phosphopeptides or phosphorylated peptides, acetylated peptides, methylated peptides, peptides with citrulline or peptide glycosylation) is crucial for many projects. JPT has extensive experience synthesizing a variety of post-translationally modified peptides, e.g. phosphopeptides and supplies post-translationally modified peptides for applications in proteomics, epigenetics and immunology. Let us know what kind of modifications you need, JPT`s experts will be happy to discuss your requirements.