MS Bioworks services

Quantitative proteomics is a powerful approach for understanding protein dynamics within a cell, tissue or organism.

Data Independent Acquisition (DIA) is an emerging quantitative proteomics technique enabling fast and sensitive protein profiling from complex mixtures. Utilizing novel scan functions and data processing workflows DIA represents a paradigm shift in the expectations associated with quantitative proteomics analysis. Our DIA services are ideally suited to the differential analysis of sample cohorts with at least three samples in each group. If you have any questions or if you would like to see how this technology could help move your research forward please reach out via phone or email.

The PTM Profiling service offered by MS Bioworks focuses on the comprehensive analysis of post-translational modifications (PTMs) on proteins. Utilizing a panel of three enzymes, this service is designed to optimize sequence coverage of target proteins, enhancing the identification, localization, and quantitation of PTMs. This service has a typical turnaround time of 2-3 weeks and provides clients with an in-depth report, available upon request, reflecting the methodology and results of the analysis. Aimed at clients seeking detailed protein characterization, the PTM Profiling Service provides valuable insights into protein modifications that are critical for understanding protein function and regulation. The service is both reliable and efficient, ensuring high-quality data that can assist in further scientific research or development processes.

The understanding of protein complex assembly and mapping of protein interactions has rapidly grown in recent years due to significant advances in mass spectrometry. Combined with selective enrichment tools we can now probe with high degree of selectivity and sensitivity protein/protein interactions and the individual networks they represent within a protein complex. Modern unbiased IP profiling approaches using mass spectrometry circumvents the need to preselect an antibody to each co-binding entity and can therefore be used for the analysis of protein complexes and enable the discovery of new functional interactions. We recommend submitting samples in control and test pairs. You can submit the elution or the matrix. For the former the elution volume should be ~50µL and for the latter the matrix should be shipped free of buffers. Our workflow is robust towards most common buffers but if you have any concerns feel free to give us a call with your questions.

These services enable the identification of proteins in a gel band, gel spot or in solution. If you would like to identify a protein in a gel band or gel spot you should select our MSB-01 service. If you would like to identify a protein in solution you should select our MSB-02 service.