Quanterix Corporation products

Introducing the world’s most sensitive, fully automated immunoassay platform with multiplexing and custom assay capability. Quanterix is re-engineering ultrasensitivity with the launch of the Simoa HD-X Analyzer™, the latest model fully automated Simoa bead-based immunoassay platform. Leveraging years of experience with the ground-breaking Simoa HD-1 Analyzer, the new flagship HD-X delivers major productivity improvements, greater user flexibility, unparalleled sensitivity, and best-in-class assay performance across a broad assay menu to empower biomarker research and accelerate drug development.

The Simoa HD-1 Analyzer is a fully automated instrument for running immunoassays using the Quanterix single molecule array, or Simoa®, platform. Simoa is a digital form of ELISA, trapping and sealing individual immunocomplexes on paramagnetic beads in thousands of femtoliter sized wells in arrays found on the Simoa Discs.  By leveraging the digital detection format of Simoa technology the HD-1 enables researchers to precisely measure protein biomarkers with substantially higher sensitivity allowing the application of precision science to precision health.

The Quanterix 2470 Arrayer produces high quality microarrays of DNA, proteins, cell lysates and a variety of other samples using its proprietary soft touch deposition technology.  The 2470 is a highly engineered platform designed with quality, reliability, flexibility and true walk-away automation in mind.  Our unique deposition technology enables printing of even complex biological samples onto a broad range of substrates such as slides, membranes, microtiter plate wells, disks, wafers and chips.

Alpha-Synuclein (α- Synuclein) is a member of the synuclein family of proteins including β-synuclein and γ-synuclein. α-Synuclein has been found concentrated in the presynaptic nerve terminals of neurons and in the nucleus of neurons. The human α-synuclein protein is made of 140 amino acids, encoded by the SNCA gene. The physiological function of α-synuclein may associate with regulating synaptic transmission, dopamine metabolism, vesicle trafficking etc. While native α-synuclein is unfolded, it has a propensity to form toxic soluble oligomers (i.e., protofibrils) that ultimately aggregate into insoluble fibrils. The fibrils and amyloidal forms of α-synuclein are major components of Lewy bodies. α-Synuclein has been linked to the pathogenesis of Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. α-Synuclein is also shown to be linked with Alzheimer’s disease.

Alpha-2 macroglobulin is a large protein found in serum and plasma and synthesized primarily by the liver. It functions as a protein inhibitor in a variety of biological functions including coagulation and fibrinolysis. Levels of alpha-2 macroglobulin in the blood have been associated with nephrotic syndrome and Alzheimer’s disease.

Angiopoietin-1 (Ang-1) is a multimeric ligand involved in the angiopoietin-Tie signaling system that activates Tie2. It is predominantly expressed by endothelial cells and some smooth muscle cells, with increased expression in many inflammatory and angiogenic conditions, such as inflammation-induced vascular remodeling and tumor angiogenesis. Ang-1 expression has been documented in a range of human cancers, including glioblastoma, melanoma, prostate adenocarcinoma, and renal cell carcinoma.

Angiopoeitin-2 (Ang-2) is a multimeric ligand involved in the angiopoietin-Tie signaling system that binds the Tie2 receptor and is characterized as a modulator of endothelial permeability and barrier function. It is predominantly expressed by endothelial cells and some smooth muscle cells, with increased expression in many inflammatory and angiogenic conditions, such as inflammation-induced vascular remodeling and tumor angiogenesis. Ang-2 expression has been documented in a range of human cancers, including glioblastoma, melanoma, prostate adenocarcinoma, and renal cell carcinoma.

Quanterix’ unique homebrew capabilities provides the flexibility for researchers to develop custom Simoa® assays. Using simple, well-established chemistry, researchers can explore significant unmet needs in life science research using digital biomarker analysis technology. Quanterix also provides the option of developing multiplex homebrew assays to minimize the sample volume, providing full kits that include all reagents and training required to develop these custom homebrew assays.