SCIREQ - an emka TECHNOLOGIES Company products

Plethysmography is a standard method for studying pulmonary function in conscious, spontaneously breathing laboratory subjects. The barometric plethysmography technique measures flow and pressure changes that occur while the subject is breathing, before and after exposure to a drug or other challenges. It is easily adapted to various subject sizes and species, and is often used for longitudinal studies where the subjects are studied for multiple hours on successive experiment days.

The expoCube is a novel Air Liquid Interface (ALI)/Transwell in vitro exposure system which permits highly reliable and effective deposition of aerosols onto cells and tissues. This exposure takes advantage of Thermophoresis, which guides small particles and gas onto the target tissue through a temperature gradient and increases the deposition rate from 2% to ~40%. The integration of the expoCube with SCIREQ’s inExpose^® inhalation exposure platform will allow researchers to combine in vitro and in vivo modelling, resulting in an effective use of compounds and better compliance with the 3Rs principle (replace, reduce, refine animal experiments).

rodentPACK for rat: rodentPACK is a digital telemetry system that can acquire up to 4 biopotentials and activity from conscious, freely moving small subjects. This cost-effective option is used on the easyTEL+ digital telemetry infrastructure, and can be customizable for either a non-invasive or implantable design. rodentPACK is particularly recommended for neurological applications, safety pharmacology and toxicology studies and drug development.

easyTEL is a fully implantable telemetry system, that transmits physiological data from conscious freely moving small subjects weighing 20 g or more, single-housed. Intended for use in preclinical research, easyTEL-S size implants are ideal for mice and offer the ability to continuously record Biopotential (ECG, EEG, EMG, EOG)* , Core Body Temperature and Activity.

Precision-Cut Lung Slices (PCLS) help researchers understand pathophysiological mechanisms associated with various respiratory diseases. The physioLens is a scientific platform that provides accurate physiological and image-based outcomes in a reproducible fashion. It includes an automated microscope and fluid handling system.

The inExpose can be configured to generate cigarette smoke, e-cigarette smoke, vaping, hookah smoke, etc. to fit a wide range of applications and budgets. Our devices are designed to produce both ISO standard and customized puff profiles, defined by the researcher. Moreover, the inExpose can be configured to deliver side-stream smoke, main-stream smoke or a mixture of both.