Toxindia services

Acute studies are short term exposure studies. It includes the other factors such as sex, species, strain, age, diet, nutritional status, general health conditions, animal husbandry, experimental procedure, route of administration, stress, dosage and formulation etc.

Sub-acute studies includes acclimatization, randomization, selection of doses, route of administration, bleeding, observations of clinical signs, urine analysis, haematology, serum biochemistry, necropsy findings, organ weights, histopathology and data analysis.

It is concern with attempting to anticipate where synthetic chemicals go in the environment and what ecological effect they have. Ecotoxicity test can be carried out at any level in the biological hierarchy of the systems ranging from molecule of the ecosystems (Calow, 1989).

Cancer is one of the leading causes of death and result from exposure to exogenous chemical. Long-term testing is to observe test animals for a major portion of these lifespan for the development of neoplasic lesions after and during exposure to various doses of a test substance by an appropriate route. The main stages of long-term assay for carcinogenicity of test article includes design, contact, analysis and reporting.

To study the compound effect on CNS or Peripheral nervous system. Main affected organs are brain, nerves, axons, and synapses. Chemically detection- blood cholinesterase Inhibition estimation Histopath- nervous tissues. Animal model used- Birds (Chicken) Rodents (Rat).

Various approaches for BA/BE Clinical trail approach. Dermatopharmacokinetic approach. Pharmacodynamic approach. Invitro release approach.

Microbial tests are to be carried out for the tests articles such as water, soil, ayurvedic powders, food products, antibiotics etc.