Basic Concepts of Toxicology for REACH and CLP Program Brochure

For full details of our ongoing programme of events visit www.reachready.co.uk Your REACH and CLP advantage Who should attend? This workshop will be of tremendous value to those who are responsible for preparing SDS, having to classify under CLP, or work on REACH registrations within their company, and who want a better understanding of the toxicology involved. Regulatory experts, consultants, health and safety advisors, product managers and legal advisors who are involved in chemical safety need a basic grasp of toxicology to understand regulatory and cost implications of the legislative demands. Likewise the day will also be beneficial for those already familiar with one scientific area but want to know about all the others. There is a discount for bookings placed up to a month before the event date. Why attend? During this workshop we will demystify the toxicology behind REACH registration and the jargon that goes with it. You’ll have a better understanding of what the experts are talking about and be able to question their recommendations, helping you to ensure that you don’t end up paying for data you don’t need, but still ensure that it is of sufficient quality to satisfy ECHA’s requirements. The day covers the toxicological hazard assessment (data endpoints) required to prepare a registration dossier and is a good introduction to toxicology. It is not our intention to go through precise practical details of how the tests are conducted, but to concentrate on concepts and results from both in-vivo and in-vitro studies. Some time will also be spent describing how toxicology data is used for classification and risk assessment. You will also leave the day with a handy reference “Laboratory Testing Guide” that that will be invaluable in your discussions ahead. We have an informal style so there will be plenty of opportunity to ask questions as we go. Outline Programme 9:00 Coffee and Registration 9:30 Introduction to Toxicology When do we need to know about Toxicology? REACH Registrations, SDS, Exposure Scenarios, CLP First steps – data gap analysis, Read across IUCLID and data input for registration 10:15 Relevance of substance identity and toxicology Understanding the chemical to be assessed Methods and interpretation Models and interpretation 10:45 Coffee 11:00 Physico-chemical property endpoints Physical properties relating to health Chemistry and health effects 11:30 Health effect endpoints Data requirements in Annexes VII – XI of REACH Types of testing in relation to exposure Exposure based data waiving In-vitro / in-vivo and use of animals 12:00 Lunch 13:00 Descriptions of methods and interpretation of data Short term studies, Irritation and sensitisation, Mutagenicity, Long term toxicology, CMR 15:00 Coffee 15:15 Use of Data Test reports and end-point assessment (examples) CLP Regulation (GHS) Discriminating dose, LD50 and Acute Toxicity Estimate (ATE) DNEL / PNEC estimations 16:30 Q & A 17:00 Close Event programme Basic Concepts of Toxicology for REACH and CLP 18 June 2013 – The Hallmark Hotel, Midland Road, Derby, DE1 2SQ