Claret - Xactly DNA Technology - Brochure

XACTLY provides comprehensive information about the native-state of fragmentary DNA termini including the type (5´, 3´ , or blunt), length, and sequence of all single-stranded overhangs. The generation of blunt ends or overhanging termini can result from physical, chemical, or enzymatic cleavage, physiologic processes or pathological mechanisms. The native termini of DNA molecules reveal information about where they have been and what they have interacted with. We initially developed XACTLY to interrogate cell-free DNA degradation. While our internal cfDNA research is ongoing, we’ve also found many other exciting applications for XACTLY including: identifying restriction enzyme cut sites, nuclease digestion preferences, and better understanding DNA degradation over time.